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·综合疾病·

降钙素原与C-反应蛋白和白细胞计数在新生儿感染性疾病诊 断应用

作者:蒋艳琼

所属单位:广州市花都区妇幼保健院(胡忠医院) (广东 广州 510800)

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摘要

目的 探析新生儿感染性疾病临床诊断中,降钙素原(PCT)、C-反应蛋白(CRP)、白细胞计数(WBC)的应用价值。方法 择取本院于2015年1月-2015年12月期间收治的新生儿感染性疾病新生儿200例为实验组;另取同期检查的健康新生 儿198例为参照组,对比两组新生儿的PCT、CRP以及WBC水平。结果 实验组及参照组的PCT、CRP以及WBC水平组间差 异统计学意义具有显著性(P<0.05),而且在新生儿感染性疾病临床诊断中,联合使用PCT、CRP、WBC,诊断灵敏度 以及特异度显著优于其它检测方法。结论 PCT、CRP以及WBC可以作为新生儿感染性疾病临床诊断的有效指标,相对 比其它检测方法而言,特异度、灵敏度显著。

Objective To investigate the application value of procalcitonin (PCT), C- reactive protein (CRP), white blood cell count (WBC) in the clinical diagnosis of neonatal infection diseases. Methods 200 cases of newborn diseased with infectious diseases admitted in our hospital from Jan. 2015 to Dec. 2015 had been selected as experimental group, while another 198 cases of healthy newborn examined in the meantime had been selected as control group, the two groups of newborn had been compared with each other in terms of PCT, CRP and WBC level. Results PCT, CRP and WBC levels were statistically significant difference between experimental group and reference group (P<0.05). The diagnostic sensitivity and specificity of combined use of PCT, CRP and WBC was significantly better than other detection methods in newborn infectious diseases. Conclusion PCT, CRP and WBC can be used as an effective indicator of neonatal clinical diagnosis of infectious diseases, which was great specificity and sensitivity compared with other detection methods.

【关键词】降钙素原;C反应蛋白;白细胞计数;新生儿;感染性疾病诊断

【中图分类号】R557

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2016.03.021

前言

现阶段,临床中新生儿系统性感染发病率非常 高,新生儿病死的可能性较大。由于该疾病临床表 现不具有特征性,难以有效判断[1]。因此,对该类疾 病进行准确的早期诊断,并及时采取有效的治疗措 施,对于提高我国医疗水平,保证新生儿安全意义显 著。当前,新生儿感染性疾病临床诊断中多联合使用 CRP、PCT指标,但WBC水平的相关报道并不常见[2]。 本院联合分析PCT、CRP以及WBC检测在新生儿感染性 疾病诊断中的应用价值,旨在进一步提高该疾病诊断 的有效性。