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下肢GCT患者术前 MRI、CT诊断与术后 复发的关系探析

作者:刘 旺 逯春梅 李梦雅 张 赣

所属单位:四川省第二中医医院放射科 (四川 成都 610031)

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摘要

目的 探讨下肢骨巨细胞瘤(GCT) 患者术前磁共振成像(MRI)、电子计算机 断层扫描(CT)诊断与术后复发的关系。方 法 回顾性分析2006-2016年5月间收治的 44例下肢GCT患者临床资料,比较CT、MRI 诊断GCT的影像学表现,根据术后是否复 发分为复发组(n=13)和无复发组(n=31), 分析术前影像学表现与术后复发的关系。 结果 在CT、MRI影像表现中,复发组与无 复发组肿瘤体积对比,差异无统计学意义 (P>0.05);在CT影像表现中,复发组与无 复发组骨嵴、骨皮质破坏出现率对比,差 异均无统计学意义(P>0.05);在MRI影像 表现中,复发组与无复发组囊性变、周围 组织血肿、软组织受侵袭、病灶边缘低信 号环不完整出现率对比,差异均无统计学 意义(P>0.05);复发组肿瘤内坏死出血出 现率高于无复发组(P<0.05)。结论 MRI术 前诊断能为判断GCT术后复发提供信息。

Objective To investigate the relationship between preoperative magnetic resonance imaging (MRI), computed tomography (CT) and postoperative recurrence in patients with lower extremity giant cell tumor (GCT). Methods The clinical data of 44 patients with lower extremity GCT admitted from 2006 to May 2016 were analyzed retrospectively. The imaging findings of GCT were compared between CT and MRI. The patients were divided into recurrence group (n=13) and non-recurrence group (n=31) according to whether the recurrence occurred after operation or not. The relationship between preoperative imaging findings and postoperative recurrence was analyzed. Results In the CT and MRI imaging findings, there was no significant difference in tumor volume between the two groups (P>0.05). In the CT imaging finding, there was no significant difference in the incidence rates of crest bone destruction and cortical destruction between the two groups (P>0.05). In MRI imaging findings, there was no significant difference in the incidence rates of cystic changes, peripheral tissue hematoma, soft tissue invasion, and incomplete low hoop of lesion edge between recurrence group and non-recurrence group (P>0.05). The incidence rate of necrotic hemorrhage in recurrence group was higher than that in non-recurrence group (P<0.05). Conclusion Preoperative MRI helps to provide information for judging the recurrence of GCT.

【关键词】下肢骨巨细胞瘤;磁共振成 像;电子计算机断层扫描

【中图分类号】R738.1;R445.2

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2019.06.043

前言

骨巨细胞瘤(giant cell tumors,GCT)是一种以局部侵袭骨质、 具有溶骨活性的良性肿瘤,多侵犯四肢长骨末端,尤以发生在膝关节 长骨骨骼成熟后骺或干骺端为代表[1]。目前GCT治疗方法以手术刮除为 主,可联合骨水泥填充等,但临床观察显示GCT术后复发率较高,达 18%~50%[2]。GCT复发不仅增加患者经济负担,二次治疗还会进一步对 患者下肢活动能力产生影响。影像学技术是临床诊断GCT的重要方式, 术前应用磁共振成像(MRI)、电子计算机断层扫描(CT)检查是了解患 者病情、评估预后的重要手段,为制定治疗方案提供有效信息。但目 前对GCT术后局部复发率与影像学特征的相关性仍存在较多争议,基于 此,本研究回顾性分析44例下肢GCT患者临床资料,以探究下肢GCT患 者术前MRI、CT诊断与术后复发的关系,现报告如下。