目的 旨在探讨不同级别脑胶质 瘤MSCT灌注成像参数比较及与血管内皮 生长因子(VEGF)表达相关性。方法 选取 我院2017年6月-2018年4月收治的脑胶质 瘤患者53例，53例患者均进行了MSCT灌注 成像，收集患者实验室资料、影像学资 料，由两名副主任级医师对CT、MRI检查 中的脑胶质瘤影像学表现特征进行总结， 分析MSCT灌注成像参数比较及与VEGF表 达相关性。结果 MSCT平扫中，脑胶质瘤 主要表现均匀或者不均匀的低密度病灶， 少数为混杂病灶，少数患者可见钙化影； MSCT增强扫描中，可有不同程度的囊变液 化坏死低密度区。灌注成像中，多数患者 肿瘤实质区灌注均较对侧同部位灌注高。 并随着灌注量的增加而表现为亮度递增的 灌注区。不同级别胶质瘤rCBV值存在明显 差异，Ⅳ级rCBV值明显高于I-Ⅱ级、Ⅲ级 者，数据差异有统计学意义(P<0.05)；不 同级别胶质瘤VEGF表达水平值存在明显差 异，随着胶质瘤级别的不断增高，VEGF表 达水平逐渐上升(P<0.001)；不同级别胶 质瘤rCBV值与VEGF表达水平呈现正相关性 (r=0.763，P<0.001)。结论 MSCT灌注成 像参数rCBV值与VEGF值存在正相关性，随 着脑胶质瘤级别的升高，rCBV值与VEGF值 逐渐上升。

Objective To compare the parameters of MSCT perfusion weighted imaging of glioma with different grades and their correlation with VEGF expression. Methods 53 patients with glioma admitted to our hospital from June 2017 to April 2018 were enrolled. All patients underwent MSCT perfusion imaging. The laboratory data and imaging data were collected.w associate chief physician summarized the imaging features of glioma in CT and MRI, and compared the parameters of MSCT perfusion weighted imaging and their correlation with expression of VEGF. Results In MSCT plain scan, glioma mainly showed uniform or uneven low-density lesions, a few were mixed lesions, and a few patients showed shadow of calcification. In the MSCT enhanced scan, there may be different degrees of low density areas with cystic liquefaction and necrosis. In perfusion weighted imaging, the perfusion of the solid area of tumor in most patients was higher than that of the same position of contralateral side,and it appeared as zone of perfusion with increasing brightness when the amount of perfusion increased.There were significant differences in rCBV values of gliomas with different grades.The rCBV values of grade IV were significantly higher than those of grades I, gradesII and grades III, the difference of data was statistically significant (P<0.05). There were significant differences in VEGF expression levels of gliomas with different grades. As grade of glioma increased, VEGF expression levels increased gradually (P<0.001). There was a positive correlation between rCBV values and VEGF expression levels in glioma of different grades (r=0.763, P<0.001). Conclusion There was a positive correlation between rCBV value and VEGF value in parameters of MSCT perfusion weighted imaging.As the grade of glioma increases, the rCBV value and VEGF value gradually increase.