目的 应用ITK-SNAP软件手动分 割、定量评价严重退变的膝关节软骨。 方法 采集32个退变严重的膝关节三维容 积磁共振数据，手动分割后计算四个软骨 单元体积、股骨髁体积，并比较各软骨单 元的差异，且进行各软骨单元与年龄、性 别以及股骨髁容积的一元、多元线性回归 分析。结果 各软骨单元体积存在显著统 计差异，且各软骨单元体积与股骨髁体积 间存在相关性，其与性别、年龄无相关 性。结论 手动分割技术能够获得严重退 变的膝关节软骨的定量数据。

Objective To quantitatively evaluate the cartilage of knee with severe degeneration by manual image segmentation with ITK-SNAP software. Methods The 3D MRI data of 32 Severely degenerative knee joints were collected, the volume of four cartilage cells and the volume of femoral condyle were calculated by manual segmentation, and the differences of each cartilage element were compared, and a single and multivariate linear regression analysis was performed for each cartilage element and age, sex and femoral condyle volume. Results There were significant differences between the volume of cartilage cells, and there was a correlation between the volume of each cartilage unit and the volume of femoral condyle, but no correlation with sex and age. Conclusion The quantitative data of the knee cartilage with severe degeneration can be obtained by manual segmentation .