目的 优化巴马小型猪颈动脉管 壁HR-MRI技术并进行重复性验证，为小 型猪颈动脉管壁病变的定性和定量研究 奠定技术基础。方法 运用3.0T MRI仪对 3只健康巴马小型猪的颈动脉管壁行高分 辨2D FSE T2WI、T1WI及T1WI增强扫描及 参数优化，重复测量和计算双侧颈动脉的 管腔面积(LA)、血管总面积(TA)及管壁 面积(WA)，变异系数(CV)和组内相关系 数(ICC)评估观察者间和观察者内的一致 性。结果 双侧颈动脉的LA、TA和WA均有 较高的观察者间一致性：CV均小于15%； ICC均大于0.4，其中所有序列的LA和TA的 ICC均大于0.90，T1WI和T1WI增强序列的 LA、TA和WA的ICC均大于0.75；观察者间 测量的差异无显著性(P>0.05)。观察者内 的一致性也较高：CV均小于15%；ICC均大 于0.4，其中LA和TA的ICC均大于0.95；观 察者内测量的差异无显著性(P>0.05)。结 论 本研究的HR-MRI优化方案提高了图像 质量，可用于巴马小型猪的颈动脉管壁形 态学的定量研究。

Objective To optimize the HR-MRI sequences of carotid arteries in Bama minipigs and to repeated measurement test. To lay the technical foundation for the qualitative and quantitative study of carotid lesion in minipigs. Methods The carotid arteries of three healthy Bama minipigs were examined by 3.0T MRI system, and the optimized high-resolution sequences included 2D FSE T2WI, T1WI and contrast enhancement. The area of lumen (LA), area of total vessel (TA) and area of wall (WA) of bilateral carotid arteries were measured or calculated repeatedly. Coefficient of variation (CV) and Intraclass correlation coefficient (ICC) were used to test the inter-observer and intra-observer agreement. Results ALL the LA, TA and WA of bilateral carotid arteries expressed good inter-observer agreement: all CVs were less than 15%, all ICCs were greater than 0.4, the ICCs of LA and TA in all sequences were greater than 0.90, and the ICCs of LA, TA and WA in T1WI and enhanced T1WI were greater than 0.75, the differences between two observers had no significance(P>0.05). Similarly, the intraobserver agreement was excellent: all CVs were less than 15%, all ICCs were greater than 0.4, the ICCs of LA and TA were greater than 0.95, the differences between twice measurements by one observer had no significance(P>0.05). Condlusion The optimized HR-MRI sequences in this study can improve the image quality, and the sequences could be used in the quantitative study of carotid morphology in Bama minipigs.