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论著-头颈部

增强CT对下咽癌患 者甲状软骨受累诊 断的价值

作者:崔 萌1 邵楠楠2 齐金星1 罗瑞华1 刘善廷1 杜 伟1 赵 铭1

所属单位:1.河南省肿瘤医院头颈甲状腺科 (河南 郑州 450008) 2.河南省肿瘤医院医学影像科 (河南 郑州 450008)

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摘要

目的 分析增强CT诊断下咽癌患 者甲状软骨受累的临床价值。方法 研究 对象为我院自2015年1月-2018年1月收治 的86例下咽癌患者,均经手术病理证实, 术前增强CT影像资料无缺失;以手术病 理结果为对照,比较增强CT诊断下咽癌 患者甲状软骨受累的临床价值。结果 86 例下咽癌患者中,54例病灶位于梨状涡, 表现为环形黏膜下浸润形态,其中29例侵 犯至杓会厌皱襞及喉腔,19例侵犯至喉旁 间隙,6例舌根部及口咽部受侵;32例位 于咽后壁,27例肿瘤外突生长,5例浸润 性生长,14例肿瘤沿咽后壁向上浸润,18 例向下浸润。71例可见不规则软组织密度 团结块,15例咽壁广泛增厚,常规CT平扫 66例为等密度或低密度,增强扫描呈明显 不均匀强化表达,且边界清晰;70例伴颈 淋巴结转移,增强扫描时可见环形强化, 9例病灶较大患者可见颈部弥漫性低密度 影。与病理结果对照,增强CT诊断下咽癌 患者甲状软骨受累的灵敏度为64.28%、特 异度为89.65%、准确率为81.39%、阳性预 测值为75.00%、阴性预测值为83.87%, kappa值0.560。结论 增强CT诊断下咽癌 患者甲状软骨受累具一定临床价值,值得 进一步深入探究。

Objective To analyze the clinical value of enhanced CT in the diagnosis of thyroid cartilage involvement in patients with pharyngeal carcinoma. Methods 86 cases of patients with hypopharyngeal carcinoma who were treated in our hospital from January 2015 to January 2018were selected for the study and were confirmed by surgical pathology, and there were no missing CT imaging data before operation. The results of surgical pathology were taken as controls to compare the clinical value of enhanced CT in the diagnosis of thyroid cartilage involvement in patients with hypopharyngeal carcinoma. Results Among the 86 patients with hypopharyngeal carcinoma, 54 lesions were located in the pear-shaped vortex and showed a ring-shaped submucosal infiltration, of which 29 cases were invaded to aryepiglottic fold and laryngeal cavity and 19 cases were invaded to the paralaryngeal space and 6 cases were invaded to tongue root and pharynx oralis. 32 cases were located in the posterior pharyngeal wall with 27 cases of tumor outgrowth and 5 cases of invasive growth, and 14 cases infiltrated upward along the posterior pharyngeal wall and 18 cases infiltrated downward. The irregular soft tissue density unity block was seen in 71 cases, and extensively thickened pharyngeal wall was shown in 15 cases, and conventional CT plain scan showed 66 cases were of equal density or low density, and enhanced scan showed obvious uneven enhancement expression and clear boundary. 70 cases were with cervical lymph node metastasis and circular enhancement was seen in the enhanced scan, and 9 patients with larger lesions were with diffuse low-density shadow of neck. Compared with pathological results, the sensitivity, specificity, accuracy, positive predictive value, negative predictive value and kappa value of enhanced CT in the diagnosis of thyroid cartilage involvement in patients with pharyngeal carcinoma were 64.28%, 89.65%, 81.39%, 75.00%, 83.87% and 0.560. Conclusion Enhanced CT has certain clinical value in the diagnosis of thyroid cartilage involvement in patients with pharyngeal carcinoma, and it deserves further investigation.

【关键词】增强CT;下咽癌;甲状软骨受 累;诊断价值

【中图分类号】R739.63

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.05.010

前言

下咽癌作为头颈部恶性肿瘤之一,以鳞状细胞癌常见,多发于梨 状窝区或下咽后壁区,其发病位置解剖构造特殊,极为隐匿,早期亦 无特异性临床症状或体征,随肿瘤生长可出现黏膜下播散、局部淋巴 结转移等病理表现,并侵犯颈部其他重要结构组织[1-2];而肿瘤组织 是否侵及甲状软骨是下咽癌T分期的决定性因素[3]。CT在下咽癌的临床 诊治中发挥一定价值,对下咽癌肿瘤黏膜下扩散程度、软骨受累情况 等信息进行表达,但受肿瘤侵犯范围、甲状软骨不规则骨化等因素影 响,评估恶性肿瘤甲状软骨受累时存在一定局限性;加之研究对象病 理分期差异,CT诊断甲状软骨受累的临床价值仍有歧义[4]。鉴于此, 现回顾性分析86例下咽癌患者的增强CT影像资料,旨在进一步补充及 完善下咽癌患者甲状软骨受累的临床诊断,具体报道如下。