目的 探究新生儿高胆红素脑病 患儿MRI及功能成像的影像表现，及MRI对 新生儿高胆红素脑病的临床诊断、鉴别诊 断价值。方法 回顾性分析临床综合为新 生儿高胆红素脑病的患儿共68例，根据 血清总胆红素水平分3组，均行MR平扫、 DWI及MRS扫描，观察不同MR系列上影像表 现及MRS各物质峰值变化，并分析以上指 标与NBE诊断的相关性。结果 68例患儿 T1WI、T2WI及T2压水序列均可检出NBE,其 中T1WI序列较其他序列具有更高的灵敏 性；3组患儿两侧大脑半球病灶T1WI信号 强度差异均无统计学意义，而组间T1WI 信号强度差异有统计学意义；T1WI高信 号病灶在MRS上表现为NAA/Cr降低，Cho/ Cr、Cho/NAA增高，其MRS表现与T1WI等信 号病灶比较，差异具有统计学意义。结论 MRI及功能成像可用于NBE的诊断，值得临 床推广。

Objective To investigate the imaging findings, diagnostic value of MRI and functional imaging in children with newborn bilirubin encephalopathy (NBE). Methods A total of 68 cases of NBE which diagnosed by clinical were analyzed retrospectively. All cases accepted MR plain scan, DWI and MRS scan and were divided into three groups according to the serum total bilirubin level. Analyze the imaging features of different MR sequences, the changes of the peak values of various substances on MRS images and the correlation with the NBE. Results Both of T1WI, T2WI and T2 water pressure sequences could be used to diagnosed NBE, and T1WI was more sensitive than the others；there was no significant difference in the bilateral T1WI signal intensity in 3 groups of children while there was significant difference among the three groups, and the T1WI high signal lesions showed the decrease of NAA/Cr and the increase of Cho/Cr, Cho/NAA in MRS. The MRS findings of T1WI high signal lesions were significantly different from those of T1WI equal signal lesions. Conclusion MRI and functional imaging could be used to the diagnosis of NBE and was worthy of clinical promotion.