目的 系统评价18F-FDG PET/ CT对肝转移瘤的诊断价值。方法 计算 机检索Pubmed、EMbase、The Cochrane Library、Web of Science、中国生物医 学文献数据库、万方数字化期刊数据库 和中国期刊全文数据库及维普数据库中 关于18F-FDG PET/CT诊断肝转移瘤的文 献，检索时间截止至2017年12月。由两 位评价员按照预定的纳入与排除标准独 立筛选文献、提取资料，按照QUADAS-2 工具评价纳入研究的偏倚风险后，采用 Stata 12.0软件进行Meta分析。结果 最 终纳入15个研究，共1628个患者，1022 个结节。Meta分析结果显示：以患者 为单位，12篇(1473例患者)PET/CT研 究的SEN合并=0.95(95%CI 0.92-0.97) SPE合并=0.94(95%CI 0.87-0.97)、 AUC=0.98(95%CI 0.97-0.99)，以病灶 为单位的6篇(1022例病灶)PET/CT研究 的SEN合并=0.82(95%CI 0.61-0.93)， SPE合并=0.95(95%CI 0.89-0.98)、 AUC=0.97(95%CI 0.95-0.98)；亚组分析 结果显示：各亚组PET/CT对肝转移瘤诊断 的AUC进行比较，差异均无统计学意义(P ＞0.05)。结论 18F-FDG PET/CT对肝转移 瘤具有较高的诊断价值，尤其是对以病人 为单位的病例具有更好的诊断敏感度。

Obejctive To evaluate the diagnostic value of PET/CT in the diagnosis of liver metastases by meta-analysis. Methods We searched databases including CNKI, CBM, VIP, WanFang Data, PubMed, EMbase, web of science and The Cochrane Library until April 2017 to collect studies about PET/CT in the diagnosis of liver metastases. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies by using the QUADAS-2 tool. Then, meta-analysis was performed by using Stata 12.0 software. Results A total of 15 studies from nine countries were included, involving 1628 patients and 1022 nodules. The results of meta-analysis showed that, the pooled sensitivity, specificity and area under SROC curve of PET/CT for diagnosing liver metastases were:a)on per-patient based, 0.95(95%CI 0.92-0.97), 0.94(95%CI 0.87-0.97) 0.98(95%CI 0.97-0.99); b) on perlesion based, 0.82(95%CI 0.61-0.93), 0.95 (95%CI 0.89-0.98), 0.97(95%CI 0.95-0.98). The results of subgroup analysis showed that no significant differences of AUC were found among all subgroups (P＞0.05). Conclusion PET/CT has a good diagnosis value for liver metastases which can be used as an noninvasion tool for suspected patients with liver metastases, especially on per-patient based.