目的 通过磁共振成像对帕金森 病(PD)患者黑质相关部位的测量，探讨 磁共振在PD早期诊断中的应用价值。方 法 利用1.5T磁共振成像系统对8例PD者 和8例正常对照组进行T2加权成像(T2WI) 的常规扫描，在T2WI上测量黑质致密带 (SNc)的宽度、中脑直径、黑质体积和黑 质信号值，计算SNc的宽度与中脑直径的 比值，比较PD患者和正常对照组之间的差 异；用统一帕金森评定量表(UPDRS)和修 订Hoehn-Yahr分级量表对PD患者进行病 情评定，分析PD患者SNc的宽度、中脑直 径、SNc宽度与中脑直径比值、黑质体积 和黑质信号值与病情的关系。结果 PD组 SNc宽度、SNc宽度与中脑直径比值低于正 常对照组(P<0.05),而PD患者中脑直径、 黑质体积和黑质信号值与正常对照组无差 异(P>0.05)，PD患者SNc的宽度、中脑直 径、SNc宽度与中脑直径比值、黑质体积 和黑质信号值与PD患者病情无相关性。结 论 常规磁共振成像有望成为PD诊断的辅 助方法。

Objective To investigate the value of magnetic resonance imaging in the early diagnosis of PD by measuring the substantia nigra related sites in patients with Parkinson's disease (PD). Methods The conventional T2 weighted imaging(T2WI) was performed in 8 patients with PD and 8 normal healthy cases as the control groups by using 1.5T magnetic resonance imaging system, the width of substantia nigra compact(SNc), diameter of midbrain, mass of substantia nigra and signal value of substantia nigra were measured on T2WI, calculated the ratio of the width of SNc to the diameter of midbrain, compared the differences between PD patients and the normal control group, the Unified Parkingson's Disease Rating Scale(UPDRS) and the revised Hoehn-Yahr rating scale were used to assess the condition of PD patients, analysised the relationship between the width of SNc, diameter of midbrain, mass of substantia nigra, signal value of substantia nigra and the condition of PD patients. Results The width of SNc, ratio of the width of SNc and diameter of midbrain in PD group were lower than those in normal control group(P<0.05), but there was no difference in the diameter of midbrain, mass of substantia nigra, signal value of substantia nigra between PD patients and normal controls (P>0.05). The width of SNc, diameter of midbrain, ratio of the width of SNc and diameter of midbrain, mass of substantia nigra, signal value of substantia nigra in PD patients were not correlated with the condition of patients. Conclusion Magnetic resonance imaging is potential to be an ancillary method for PD.