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MRI在评估2型糖尿病患者脑部小血管损伤的临床价值

作者:曾旭东1 周旭峰2 温 辉1

所属单位:1.郑州大学附属洛阳市中心医院神 经外科 (河南 洛阳 471001) 2.郑州大学附属洛阳市中心医院磁 共振室 (河南 洛阳 471001)

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摘要

目的 探讨磁共振成像(MRI)在评 估2型糖尿病患者脑部小血管损伤的临床 价值。方法 选择医院2017年3月-2018年 3月收治的神经内科患者120例,按有无2 型糖尿病分为2型糖尿病组(60例)和无糖 尿病组(60例),两组均接受MRI扫描,对 比两组患者的急性梗塞发生情况及类型、 脑内微出血、腔隙性梗塞及脑白质疏松程 度。结果 2型糖尿病组患者与无糖尿病组 相比,急性梗塞及小血管型梗塞发生率较 高,大血管型梗塞发生率较低,差异有统 计学意义(P<0.05)。2型糖尿病组患者腔 隙性梗塞灶及脑白质疏松程度均高于对照 组,差异有统计学意义(P<0.05)。结论 MRI可显示急性梗塞发生情况及类型、脑 内微出血灶、腔隙性梗塞灶及脑白质疏松 程度,对2型糖尿病患者脑部小血管损伤 的评估具有诊断价值。

Objective To investigate the clinical value of magnetic resonance imaging (MRI) in the evaluation of cerebral small vascular injury of patients with type 2 diabetes mellitus. Methods A total of 120 cases of patients admitted to department of neurology in hospital from March 2017 to March 2018 were selected and divided into 2 types, diabetes mellitus type 2 group (60 cases) and non-diabetes group (60 cases) according to the presence or absence of type 2 diabetes mellitus. Two groups were given MRI scan. The occurrence and types of acute infarction, intracerebral microbleeds, lacunar infarction and leukoaraiosis were compared between the two groups. Results Compared with nondiabetes group, the incidence rates of acute infarction and small vessel infarction were higher in type 2 diabetes mellitus group while the incidence rate of large vessel infarction was lower(P<0.05). The degrees of lacunar infarction and leukoaraiosis in type 2 diabetes mellitus group were higher than those in non-diabetes group (P<0.05). Conclusion MRI can show the occurrence and types of acute infarction, and the degrees of intracerebral microbleeds, lacunar infarction and leukoaraiosis. And it has diagnostic value for the assessment of cerebral small vascular injury in patients with type 2 diabetes mellitus.

【关键词】2型糖尿病;磁共振成像;脑 部小血管损伤

【中图分类号】R445.2

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2019.01.014

前言

高血糖状态是引起组织细胞受损的关键因素,其引起的脑部血管 损伤会继发一系列病理性改变,如脑卒中、脑内微出血、腔隙性梗塞 灶、脑白质病变等。有研究发现,糖尿病会导致认知功能、脑结构及 神经生理异常,即“糖尿病脑病”[1-3]。因此尽早发现,及时治疗是临 床治疗2型糖尿病脑病的关键[4-5]。近年来,随着MRI成像序列、图像清 晰度的不断改善,为脑部病变的评估提供了良好的依据,且MRI因其检 查方式无创、操作简单而在脑动脉检查方面有很大优势。研究表明, MRI在检查脑部小血管损伤时具有良好的效果[6]。本研究通过MRI对2型 糖尿病患者的脑部小血管损伤进行评估,旨在为临床2型糖尿病脑部小 血管损伤的诊断提供一定依据。现报道如下。