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MRI在脑胶质母细胞瘤的诊断价值

作者:阿不都克尤木·阿不拉1 帕力丹木·吾买尔1 黄杰灵2 成官迅3

所属单位:1.新疆喀什地区第一人民医院影像科(新疆 844000) 2.南方医科大学第五附属医院影像科(广东 广州 510900) 3.北京大学深圳医院影像科(广东 深圳 518036)

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摘要

目的分析胶质母细胞瘤的MRI表 现,旨在提高脑胶质母细胞瘤的诊断正确 率。方法 回顾性分析2012年9月至2017年 9月于我院经手术病理证实胶质母细胞瘤 55例MRI资料。结果 在55例患者中,额叶 13例,其中单独在额叶4例,其余9例均不 同程度侵犯邻近脑叶;颞叶26例,其中单 独在颞叶11例,14例侵犯邻近侧脑室,1 例在侧脑脑室内独立成瘤灶;顶叶7例, 枕叶9例。脑胶质母细胞瘤具有较快的生 长速度,一般在发现时,瘤体均已较大, 形态以不规则为主;MRI分型可分为囊变 坏死型、出血型、多发型,其表现主要以 T1WI低信号及T2WI高信号为主,以不均匀 强化为多见,有时肿瘤内可见异常增生血 管影,周围出现II-III度水肿及较重的占 位效应。结论 MRI对胶质母细胞瘤的诊断 具有较高临床价值;胶质母细胞瘤的MRI 表现具有一定特征性,术前多能做出正确 诊断。

Objective To analyze the MRI findings of glioblastoma in order to improve the diagnostic accuracy of glioblastoma. Methods MRI data of 50 cases of glioblastoma confirmed by surgery and pathology in our hospital from September 2012 to September 2017 were retrospectively analyzed. Results Of the 55 patients, 13 were frontal lobe, 4 of which were located in the frontal lobe alone, and the other 9 had different degrees of invasion of adjacent brain parenchyma. 26 cases were located in temporal lobe, 11 in temporal lobe alone, 14 in adjacent lateral ventricles, and 1 in the lateral ventricles. There were 7 cases in the parietal lobe and 9 cases in the occipital lobe. Glioblastoma has a relatively fast growth rate, and in general, the tumors are larger and irregular in shape. MRI classification can be divided into cystic degeneration, death, hemorrhagic and multiple types. The main manifestations were T1WI low signal and T2WI high signal mainly with uneven enhancement. Sometimes there was abnormal proliferation of vascular shadow in the tumor, and II-III degree edema and heavy occupying effect appeared around the tumor. Conclusion MRI is of high clinical value in the diagnosis of glioblastoma. The MRI findings of glioblastoma have certain characteristics and can be correctly diagnosed before operation.

【关键词】脑胶质母细胞瘤;MRI;诊断价值

【中图分类号】R739.41;R445.2

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.09.024

前言

胶质瘤是肿瘤中较为常见的中枢神经系统原发性的肿瘤,脑肿瘤 中约有半数为胶质瘤。胶质母细胞瘤是指发生在成年人的脑中枢神经 之上皮性质肿瘤,因为肿瘤细胞属于多形性,故也称之为多形性胶质 母细胞瘤,在脑肿瘤中占比12~20%,在神经上皮肿瘤中占比约22%, 在星形细胞瘤中占比约60~70%,具有较高的致残率与病死率[1-2]。脑 肿瘤生长速度迅猛,患者会广泛出现水肿,致使颅内压明显增高, 临床症状为头痛、呕吐、精神异常及肢体无力与意识和语言出现障 碍[3]。随着医疗技术的提高及影像学技术水平的高速发展,X线及CT、 MRI出现,特别是MRI在诊断中的应用,大大增加了该病在诊断中的发 现机率。本文回顾性分析55例经手术病理证实的脑胶质母细胞瘤的MRI 表现特点,以提高对该肿瘤的认识和诊断水平。