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18F-FDG PET/CT显像在肺外结核诊断中的应用价值*

作者:倪 明 汪世存 潘 博 展凤麟 刘 昕 张依凡

所属单位:中国科学技术大学附属第一医院(安徽省立医院)PET/CT中心(安徽 合肥 230001)

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摘要

目的探讨肺外结核在18F-FDG PET/CT显像的特点和征象,以提高对肺外 结核的认识和诊断水平。方法 回顾性分 析经病理和实验室检查确诊为肺外结核的 23例患者的18F-FDG PET/CT资料,测量活 性病灶SUVmax,进行半定量分析。结果 23 例肺外结核患者共41处病灶,有13例患者 合并2种及以上多处肺外结核,除了1处肝 结核和1处颅内结核,其余均表现为18FFDG代谢不同程度增高,SUVmax2.9-28.3, 根据肺外结核的发病部位大致分四大类: ①淋巴结结核,主要表现为淋巴结不同程 度的肿大,部分伴有钙化;②浆膜结核, 包括胸膜和腹膜结核,主要以弥漫性增厚 为主,部分呈结节样增厚;③骨结核, 均呈溶骨性骨质破坏改变,部分伴椎间盘 受累及椎旁脓肿形成;④脏器结核,肝、 脾结核可见软组织结节及肿块影,输尿管 结核可见管壁增厚、继发肾积水,附件结 核主要表现为软组织增厚、输卵管迂曲增 粗,回盲部结核表现为肠壁环形增厚,肠 腔变窄,颅内结核表现为颅内多发结节灶 伴周围水肿。另有一例患者同时出现右侧 臀部软组织肿块影。结论 18F-FDG PET/ CT全身显像有利于显示肺外结核的病变部 位、形态及代谢特点,对肺外结核的早期 诊断和鉴别诊断有一定的临床价值。

Objective To investigate the characteristics and signs of 18F-FDG PET/CT imaging in extrapulmonary tuberculosis, so as to improve the understanding and diagnosis level of extrapulmonary tuberculosis. Methods The 18F-FDG PET/CT data of 23 patients with extrapulmonary tuberculosis diagnosed by pathology and laboratory examinations were retrospectively analyzed. The SUVmax of the active lesion was measured with the results subject to the semi-quantitative analysis. Results There were a total of 41 lesions in 23 patients with extrapulmonary tuberculosis, 13 patients with multiple extrapulmonary tuberculosis. Except for one site of liver tuberculosis and one site of intracranial tuberculosis, the rest showed varying degrees of the increase in 18F-FDG metabolism, SUVmax2.9-28.3. According to the pathogenesis site, extrapulmonary tuberculosis was roughly divided into four types: (1) lymph node tuberculosis, mainly characterized by lymph nodes in varying degrees of swelling of which some were with calcification. (2) serous tuberculosis, including pleura and peritoneal tuberculosis, mainly characterized by the diffuse thickening (as a main phenomenon), some nodular thickening. (3) bone tuberculosis, characterized by osteolytic bone destruction, some with intervertebral disc involvement and paraspinal abscess formation, (4) organ tuberculosis (liver and spleen tuberculosis was found with soft tissue nodules and masses; ureteral tuberculosis with wall thickening and secondary hydronephrosis, annex tuberculosis was mainly characterized by soft tissue thickening, tubal tortuous thickening, ileocecal tuberculosis was characterized by intestinal wall ring-shaped thickening, narrowing of intestinal cavity, intracranial tuberculosis was characterized by multiple intracranial nodules with peripheral edema. There was one patient with concurrent soft tissue mass in the right side of the buttock. Conclusion 18F-FDG PET/CT imaging is helpful to show the location, morphology and metabolic characteristics of pulmonary tuberculosis, which is of great clinical value in the early diagnosis and differential diagnosis of extrapulmonary tuberculosis.

【关键词】肺外结核;体层摄影术;正电子发射断层显像术;脱氧葡萄糖

【中图分类号】R521

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.09.009

前言

结核病(tuberculosis,TB)的发病率和死亡率都很高,一些肺外 结核(extrapulmonary tuberculosis,EPTB)的发病率也在逐年上升。 在全球范围内,其死亡率位于感染性疾病死亡的第二位,仅次于人类 免疫缺陷病毒(human immunodeficiency virus,HIV)[1]。由于TB的多 样性和复杂性,因此对TB的诊断、治疗和疗效监测的手段要求越来越 高。PET/CT作为一种分子影像成像,能将结核病变的药理学,免疫学 和微生物学与解剖信息联系起来[2]。常用的显像剂为氟[18F]标记的脱 氧葡萄糖(18F-FDG),活动性结核杆菌在肺部和肺外病变中都摄取18FFDG[3]。现回顾性分析我院经病理和临床确诊的EPTB病例,总结其在 18F-FDG PET/CT上的特点,旨在提高对EPTB的认识和诊断水平。