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18F-FDG PET/CT在乳腺癌诊断和术前分期评估中的价值研究*

作者:彭雪强 任 谊 魏庆忠 王 钢 苏超云 郭 雯

所属单位:北京航天总医院普外科(北京 100076)

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摘要

目的研究18F-脱氧葡萄糖(18FFDG)PET/CT在乳腺癌诊断和术前分期评估 中的价值。方法 将我院收治的69例疑似 乳腺癌患者作为研究对象,均于术前进行 18F-FDG PET/CT检查,以术后病理结果为 标准,分析18F-FDG PET/CT对乳腺癌诊断 的信效度及与病理结果诊断一致性,并分 析18F-FDG PET/CT对术前分期信效度。结 果 69例患者术后病理结果显示为乳腺癌 者67例,18F-FDG PET/CT检查结果显示SUV 阳性者65例,阴性者4例,18F-FDG PET/ CT乳腺癌诊断诊断灵敏度为97.01%,特 异度为100.00%,准确度为97.10%,与病 理结果诊断一致性较好(κ=0.896)。18FFDG PET/CT检查确诊为乳腺癌的65例患者 中,术后病理结果显示I期者6例,II期 者35例,III期者8例,IV期者16例;18FFDG PET/CT检查显示I期者7例,II期者32 例,III期者11例,IV期者15例;18F-FDG PET/CT检查对乳腺癌术前分期诊断总准确 度为89.23%。结论 18F-FDG PET/CT乳腺 癌诊断准确性较高,能较好评估术前肿瘤 分期。

Objective To study the value of 18F-FDG PET/CT in diagnosis and preoperative staging assessment of breast cancer. Methods A total of 69 cases of patients with suspected breast cancer treated in our hospital were selected for the study and were given 18F-FDG PET/CT before operation. The postoperative pathological results were used as criteria to analyze the reliability and validity of 18F-FDG PET/CT and its consistency with pathological diagnosis in the diagnosis of breast cancer and to analyze the reliability and validity of 18F-FDG PET/CT to preoperative staging. Results The postoperative pathological results of 69 cases showed there were 67 cases of breast cancer, and the results of 18F-FDG PET/CT showed that 65 cases were SUV positive and 4 cases were negative, and the diagnostic sensitivity, specificity and accuracy of 18F-FDG PET/ CT were 97.01%, 100% and 97.10% in the diagnosis of breast cancer, and its consistency with pathological diagnosis was better (κ=0.896). Among 65 cases diagnosed with breast cancer by 18F-FDG PET/CT, postoperative pathological results showed that there were 6 cases in I stage, 35 cases in II stage, 8 in III stage and 16 in IV stage. 18F-FDG PET/ CT showed that there were 7 cases in I stage, 32 cases in II stage, 11 in III stage and 15 in IV stage. The total accuracy of 18F-FDG PET/CT was 89.23% in the diagnosis of preoperative staging of breast cancer. Conclusion 18F-FDG PET/CT has high diagnostic accuracy in breast cancer, and can better evaluate preoperative tumor staging.

【关键词】18F-FDG PET/CT;乳腺癌;诊断;术前分期

【中图分类号】R737.9

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.09.013

前言

乳腺癌是女性常见肿瘤,发生率高,调查显示乳腺癌发病率占女 性恶性肿瘤第一顺位,已成为当前社会重点关注公共卫生问题[1]。乳 腺细胞发生肿瘤变异后较易脱落游离,随体液播散全身,患者会出现 肿瘤周围浸润和全身重要脏器转移,直接威胁生命安全[2]。目前临床 多通过影像学手段诊断乳腺癌,18F-脱氧葡萄糖(18F-FDG)PET/CT是兼备 功能与形态学的影像学方法,对癌症诊断和转移均有较高价值[3]。本 次研究对我院69例疑似乳腺癌患者进行术前18F-FDG PET/CT检查,探讨 其在乳腺癌诊断和术前分期评估中的价值。具体报告如下。