摘要
目的探讨电子计算机断层扫 描(Computed Tomography,CT)与核磁 共振(Magnetic Resonance Imaging, MRI)在原发性肝癌(primary hepatic carcinoma,PHC)介入术后病灶残留及复 发中的应用价值。方法 选取本院2015 年6月-2017年6月收治的PHC患者60例为 研究对象,共84个病灶,患者均在行经 导管肝动脉化疗栓塞术(transarterial chemoembolization,TACE)后2-6个 月来院复查,采用CT、MRI和数字减 影血管造影 ( D i g i t a l S u b t r a c t i o n Angiography,DSA)检查。以DSA为金标 准,比较CT和MRI检查对术后病灶残 留、复发诊断的准确度、敏感度、特异 度,以及对病灶肿瘤包膜的检出率。结 果 CT病灶残留或复发诊断准确度、敏 感度、特异度分别为79.76%、72.58%和 100.00%,MRI病灶残留或复发诊断准确 度、敏感度、特异度分别为94.05%、 91.94%和100.00%,MRI诊断的准确度和 敏感度显著高于CT(P<0.05);CT肿瘤包 膜检出率为3.57%,显著低于MRI肿瘤包 膜检出率10.71%(P<0.05)。结论 MRI对于 PHC患者TACE术后疗效诊断准确度高,明 显优于CT诊断。
Objective To explore the application values of CT and MRI in the lesion residues and recurrence of primary hepatic carcinoma (PHC) intervention. Methods A total of 60 cases of PHC patients treated in our hospital from June 2015 to June 2017 were selected for the study with a total of 84 lesions, and all the patients were given the review at 2-6 months after the transarterial chemoembolization (TACE). The CT, MRI and digital subtraction angiography (DSA) were performed. The accuracy, sensitivity, specificity of the lesion residues and recurrence and the detection rate of the lesion tumor capsule were analyzed by CT and MRI examination taking the DSA as the gold standard. Results The accuracy, sensitivity and specificity of lesion residues and recurrence were 79.76%, 72.58% and 100.00% respectively by CT and were 94.05%, 91.94% 100.00% by MRI, and the accuracy and sensitivity of MRI diagnosis were significantly higher than those by CT (P<0.05). The detection rate of the lesion tumor capsule by CT was significantly lower than that by MRI (3.57% vs 10.71%) (P<0.05). Conclusion MRI has the high accuracy of efficacy diagnosis for PHC patients after TACE, which is significantly better than the CT diagnosis.
【关键词】CT;核磁共振;原发性肝癌;行经导管肝动脉化疗栓塞术;病灶残留及复发
【中图分类号】R735.7
【文献标识码】A
【DOI】10.3969/j.issn.1672-5131.2018.07.029
前言
原发性肝癌(primary hepatic carcinoma,PHC)是我国中年以上 男性好发的恶性肿瘤之一,发病原因可能与病毒性肝炎、肝硬化、 化学致癌物质以及环境等因素相关。PHC患者一般表现为肝脏进行性 肿大、肝区疼痛、消瘦、乏力、呕吐、腹泻等症状[1-2]。手术根治性 切除是PHC治疗最有效的方法,但因PHC早期无明显临床症状、发病 迅速且易转移,许多患者确诊时已失去手术治疗机会[3]。对于无法 进行手术治疗的患者,行经导管肝动脉化疗栓塞术(transarterial chemoembolization,TACE)不仅可对肿瘤进行药物化疗,还可阻断肿 瘤动脉供血,对预后有积极作用,是目前PHC非手术治疗的首选方法 [4]。然而PHC患者TACE术后疗效的客观、准确评价也十分重要,以往常 采用数字减影血管造影(Digital Subtraction Angiography,DSA)和电 子计算机断层扫描(Computed Tomography,CT)技术评价治疗疗效,随 着磁共振成像(Magnetic Resonance Imaging,MRI)技术的发展和普 及,其在TACE术后疗效评估方面也得到广泛应用。本研究旨在比较CT 和MRI对PHC患者TACE术后病灶残留及复发等评估的应用价值,现报道 如下。
中国CT和MRI杂志
第16卷, 第 7 期
2018年07月
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