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3.0T MRI常规序列联合DWI对肺癌术前T、N分期的诊断价值及其与病理的相关性研究*

作者:胡秀峰 陈利娟 赵艳秋

所属单位:郑州大学附属肿瘤医院呼吸内科(河南 郑州 450008)

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摘要

目的研究3.0T磁共振成像(MRI) 常规序列联合扩散加权成像(DWI)对肺癌 术前T、N分期的诊断价值及其与病理的相 关性。方法 选择我院2015年8月至2017 年7月收治的肺癌患者71例,均进行3.0T MRI常规序列联合DWI检查,以术后病理 结果作为标准,分析3.0T MRI常规序列 联合DWI检查对术前T、N分期结果及与病 理结果相关性。结果 71例患者3.0T MRI 常规序列联合DWI扫描对肺癌术前T分期 诊断总精确度为92.96%,T1-2期灵敏度、 特异度和准确度依次为80.00%、100.00% 和98.59%;T3期灵敏度、特异度和准确度 依次为87.50%、94.55%和92.96%;T4期灵 敏度、特异度和准确度依次为96.00%、 90.48%和94.37%;与病理结果进行诊断一 致性检验(κ=1.416,P>0.05)。71例患 者3.0T MRI常规序列联合DWI扫描对肺癌 术前N分期诊断总精确度为91.55%,N0期 灵敏度、特异度和准确度依次为94.74%、 96.97%和95.77%;N1期灵敏度、特异度和 准确度依次为89.47%、92.31%和91.55%; N2-3期灵敏度、特异度和准确度依次为 85.71%、98.25%和95.77%;与病理结果进 行诊断一致性检验(κ=0.748,P>0.05)。 结论 3.0T MRI常规序列联合DWI可作为肺 癌术前T、N分期诊断的重要方法,与病理 结果一致性较高。

Objective To study the diagnostic values of 3.0T magnetic resonance imaging (MRI) routine sequence combined with diffusion-weighted imaging (DWI) in preoperative T and N stages of lung cancer and its correlation with pathology. Methods A total of 71 cases of patients with lung cancer treated in our hospital from August 2015 to July 2017 were selected and were given 3.0T MRI routine sequence combined with DWI examination. The postoperative pathological results were taken as criterion, and the preoperative T and N stages results of 3.0T MRI combined with DWI and its correlation with pathological findings were analyzed. Results The total accuracy of preoperative T stage in 71 patients was 92.96% by 3.0T MRI combined with DWI scan. The sensitivity, specificity and accuracy were 80.00%, 100.00% and 98.59% respectively at T1-2 stage, and were 87.50%, 94.55% and 92.96% respectively at T3 stage and were 96.00%, 90.48% and 94.37% at T4 stage. The results of consistency test diagnosis with pathology showed κ=1.416 (P>0.05). The total accuracy of preoperative N stage in 71 patients was 91.55% by 3.0T MRI combined with DWI scan. The sensitivity, specificity and accuracy were 94.74%, 96.97% and 95.77% at N0 stage, and were 89.47%, 92.31% and 91.55% at N1 stage and were 85.71%, 98.25% and 95.77% at N2-3 stage. The results of consistency test diagnosis with pathology showed κ=0.748 (P>0.05). Conclusion 3.0T MRI routine sequence combined with DWI can be used as important method for preoperative T and N stages of lung cancer diagnosis, and the consistency is high with pathological results.

【关键词】磁共振成像;扩散加权成像; 肺癌;分期;病理

【中图分类号】R445.2;R734.2

【文献标识码】A

【DOI】10.3969/j.issn.1672-5131.2018.07.001

前言

肺癌发病率和致死率均较高,是临床最为常见的恶性肿瘤之一, 近年来众多调查显示,肺癌发病率和死亡率呈上升趋势,对人类健康 和生命安全造成重大威胁[1]。目前认为肺癌病因与吸烟、职业环境、 慢性肺部感染等密切相关[2]。肺癌临床表现较为复杂,早期症状多不 明显,待发现时多已处于癌症中晚期,治疗困难且预后较差。外科手 术是肺癌首选和最主要治疗方法,但如何制定手术和辅助治疗方案受 术前患者T、N分期影响[3]。为提高诊疗效果,本次研究采用3.0T磁共 振成像(MRI)常规序列联合扩散加权成像(DWI)对肺癌患者术前T、N分 期进行诊断,并分析其与病理的相关性。具体报告如下。