目的探讨静息态下功能磁共振 下青少年首发未用药精神分裂症患者脑内 环路的异常。方法 纳入33例青少年首发 未用药精神分裂症(患者组)和34名正常青 少年(对照组)为研究对象，均接受静息态 功能磁共振扫描(rs-fMRI)；采用低频振 幅(ALFF)方法对数据进行分析，进行独立 样本t检验后分析静息态脑功能的差异。 结果 患者组在左侧颞下回、右侧海马、 右侧尾状核、丘脑ALFF值升高，后扣带 回、顶下小叶ALFF值降低，差异均有统计 学意义(P﹤0.01)。结论 青少年精神分裂 症的发病机制可能与纹状体-丘脑-默认网 络环路中部分脑区功能异常有关。

Objective To explore the abnormality of the inner loop in the patients with schizophrenia under the condition of resting state functional magnetic resonance image. Methods The subjects were included in 33 adolescents with untreated schizophrenia (group of patients) and 34 normal adolescents (control group), all of whom were subject to the resting-state functional magnetic resonance image (rs-fMRI).The data were analyzed by using amplitude of low-frequency fluctuation (ALFF) method, and the difference of resting brain function was analyzed after independent sample t test. Results The patients group increased in the left temporal gyrus, right hippocampus, right caudate nucleus, and thalamus ALFF, and decreased the ALFF value in the posterior cingulate cortex and the lower lobe, and the difference was statistically significant (P<0.005). Conclusion The pathogenesis of adolescent schizophrenia may be related to the functional abnormality of some brain regions in the striatum - thalamus - the default network loop.