目的 探讨3.0T磁共振全身扩散 加权成像(WB-DWI)在急性白血病(AL)患 者治疗随访过程中骨髓浸润监测的应用 价值。方法 分析2016年7月至2017年10 月在本院治疗的30例AL患者的临床及影 像资料，将患者治疗前、治疗中、治疗 后的WB-DWI图像及ADC值与临床疗效进行 对比分析，探讨WB-DWI在急性白血病患 者治疗过程中临床疗效的监测价值。结 果 30例AL患者经多个疗程诱导治疗后， 完全缓解(CR)19例，部分缓解(PR)6例， 未缓解(NR)5例。CR、PR患者治疗后WBDWI骨髓信号高于治疗前，NR患者治疗 前、中、后骨髓信号变化不明显。CR、 PR患者治疗前、治疗中、治疗后三组间 ADC值两两对比差异均具有统计学意义(P ＜0.05)；NR患者治疗前、治疗中、治 疗后三组间ADC值两两对比差异无统计学 意义(P＞0.05)；CR与PR患者治疗中ADC 值差异、治疗后ADC值差异均无统计学意 义。结论 WB-DWI在急性白血病患者治疗 随访过程中具有一定监测价值，可以一 定程度的减少骨髓穿刺次数。

Objective To investigate the application value of 3.0T magnetic resonance whole-body diffusion weighted imaging (WB-DWI) in the treatment of acute leukemia (AL) patients during follow-up. Methods Clinical and imaging data of 30 AL patients treated in our hospital from July 2016 to October 2017 were analyzed. Comparative analyse WB-DWI images and ADC values with clinical efficacy of patients priortreatment, under-treatment and post-treatment. To evaluate the monitoring value of clinical efficacy of WB-DWI in the treatment of acute leukemia patients. Results 30 patients with AL were treated with multiple courses of chemotherapy,19 cases were complete remission(CR), 6 cases were partial remission(PR), 5 cases were non-remission (NR).The bone marrow signal of WB-DWI after treatment in patients with CR and PR is higher than before treatment, The changes of bone marrow signal before, during and after treatment in NR patients were not obvious. The difference of ADC value of CR and PR patients before, under and after treatment was statistically significant (P<0.05) while pairwise contrast of the three group. There was no significant difference in ADC between the three groups before, during and after treatment in NR patients (P>0.05).There was no significant difference in ADC value between CR and PR patients under-treatment and after treatment. Conclusion WB-DWI has a certain value in the monitoring of acute leukemia patients during follow-up treatment, can reduce the number of bone marrow aspiration to a certain extent.