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MRI在直肠癌术前TN 分期中的诊断价值

作者:闫少华 李振玉 牛永超 刘 斌 王 娟

所属单位:新乡市中心医院医学影像科 (河南 新乡 453000)

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摘要

目的 探讨磁共振成像(MRI)在直 肠癌术前TN分期中的诊断价值。方法 选 取2016年2月至2017年3月在我院治疗的直 肠癌患者68例,术前行MRI扫描,扫描序 列包括T2WI和磁共振弥散加权成像(DWI) (b=0,1000s/mm2 ),分析T2WI术前TN分期 与术后病理结果,DWI测量不同T分期病 灶表观弥散系数(ADC)值。结果 术后病 理T分期:≤T2期10例、T3期39例、T4期 19例;术后病理N分期:N0期45例、N1期 17例、N2期6例;MRI术前T分期与病理结 果一致性Kappa值=0.642,P<0.05,MRI 术前T分期准确率为79.41%;MRI术前N分 期与病理结果一致性Kappa值=0.244,P <0.05,MRI术前N分期准确率为57.35%; T1+2期病灶ADC值为(1.104±0.122)×10- 3 mm2 /s,明显高于T3期和T4期(P<0.05)。 结论 MRI在直肠癌术前T分期诊断中有较 好的应用价值,在N分期诊断中准确率较 低;ADC值在术前T分期诊断中有一定价 值。

Objective To investigate the diagnostic value of magnetic resonance imaging (MRI) in the preoperative TN staging of rectal cancer. Methods 68 cases of rectal cancer treated in our hospital from February 2016 to March 2017 were selected, MRI scan was performed before the operation, and the scanning sequence included T2WI and magnetic resonance diffusion weighted imaging (DWI) (b=0,1000s/mm2 ). The preoperation TN staging of T2WI and postoperative pathological results were analyzed, the apparent diffusion coefficient (ADC) of different T staging lesions (ADC) was measured by DWI. Results The postoperative pathological T staging: 10 cases of ≤T2, 39 cases of T3, 19 cases of T4, postoperative pathological N staging: 45 cases of N0, 17 cases of N1, 6 cases of N2. The Kappa value of T staging of MRI before operation and pathological results was=0.642, P<0.05, and the accuracy rate of T staging of MRI before operation was 79.41%. The Kappa value of N staging of MRI before operation and pathological results was=0.244, P<0.05, and the accuracy rate of N staging of MRI before operation was 57.35%. The ADC value of the T1+2 phase was (1.104±0.122)×10-3mm2 /s, which was significantly higher than that of T3 and T4 (P<0.05). Conclusion MRI has a good application value in the diagnosis of preoperative T staging of rectal cancer, and its N stage diagnosis accuracy is low. ADC value plays a certain role in preoperative T stage diagnosis.

【关键词】磁共振成像;直肠癌;T分 期;N分期;磁共振弥散加权 成像;表观弥散系数

【中图分类号】R735.3+7;R445.3

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2018.06.035

前言

直肠癌是发病率较高的恶性肿瘤之一,病因主要有遗传因素、饮 食结构的改变等,其发病率呈现逐年上升的趋势[1]。按照美国癌症联合 委员会(AJCC)对直肠癌分期系统,可将直肠癌进行TNM期分期[2]。手术 切除是目前临床上治疗结肠癌最有效的手段。但术后复发率较高。有 研究报道[3]直肠癌术后2年总的局部复发率约3%~32%,其主要原因有肿 瘤的局部浸润、淋巴转移和远处转移等。且有文献报道[4]环状切除边缘 距离是影响术后复发的主要因素。故评估术前分期并确定切除边缘对 预后和复发率影响很大。这就需要敏感科学的诊断方法。MRI对软组织 的分辨率较高,可很好的反映肿瘤的浸润和侵犯的程度和范围。且高 频率的MRI能识别2~3mm大小的淋巴结,对淋巴结转移具有较好的预测 作用[5]。本研究利用T2WI联合DWI对直肠癌进行术前TNM分期并与病理结 果进行对照,初步探讨ADC值在直肠癌恶性程度评估过程中的价值。现 将报道如下。