摘要
目的 探讨MRI在宫颈癌术前病 情评估中的临床价值。方法 回顾性分析 59例宫颈癌初诊患者术前MRI检查宫颈 癌肌层浸润、阴道受累、宫旁浸润、淋 巴结转移的影像学资料,并与术后病理 学结果进行比较,观察比较与术后病理 分期诊断的准确性及一致性,同时探讨 MRI对宫颈癌肌层浸润、阴道受累、宫 旁浸润、淋巴结转移诊断的灵敏度、特 异度、阳性预测值、阴性预测值、准确 率。结果 以术后病理学检查为金标准, 术前MRI分期诊断与术后病理分期检查结 果一致性Kappa=0.64,P<0.001,其诊断 符合率为79.66%。术前MRI对肌层浸润、 阴道受累、宫旁浸润、淋巴结转移的灵 敏度分别为77.78%、73.91%、87.18%和 77.78%,特异度分别为98.0%、96.11%、 80.0%和94.0%,诊断准确率分别为 94.92%、81.36%、84.75%和91.53%, 且检验一致性分别为Kappa=0.794、 0.605、0.664和0.687,P<0.001。结论 MRI对于宫颈癌术前分期具有较高准确 率,且对宫颈癌肌层浸润、阴道受累、 宫旁浸润、淋巴结转移具有较高的敏感 度、特异度和准确率,MRI对宫颈癌术前 病情评估具有重要临床价值。
Objective To explore the clinical value of MRI in preoperative condition evaluation of cervical cancer. Methods The imaging data of 59 cervical cancer patients treated with preoperative MRI examination about myometrial infiltration, vaginal involvement, parametrial infiltration and lymph node metastasis were analyzed retrospectively. The postoperative pathological findings were compared with MRI examination, the accuracy and consistency of the postoperative pathological staging diagnosis were observed and compared. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MRI in the diagnosis of myometrial infiltration, vaginal involvement, parametrial infiltration and lymph node metastasis were also discussed. Results The pathological examination was taken as the gold standard, and the preoperative MRI staging diagnosis and the postoperative pathological staging examination were consistent with Kappa=0.64 and P<0.001, and the diagnostic accuracy rate was 79.66%. The sensitivity of MRI for preoperative myometrial infiltration, vaginal involvement, parametrial infiltration and lymph node metastasis were 77.78%, 73.91%, 87.18% and 77.78%, and the specificity were 98%, 96.11%, 80% and 94% respectively, and the accuracy rate of diagnosis were 94.92%, 81.36%, 84.75% and 91.53%, and the consistency were Kappa=0.794, 0.605 , 0.664 and 0.687, P<0.001. Conclusion MRI has a high accuracy rate for preoperative staging of cervical cancer, and has high sensitivity, specificity and accuracy to cervical myometrial infiltration, vaginal involvement, parametrial infiltration and lymph node metastasis, therefore MRI has important clinical value on cervical cancer preoperative condition evaluation.
【关键词】MRI;宫颈癌;评估;临床价值
【中图分类号】R737.33;R445.2
【文献标识码】A
【DOI】 10.3969/j.issn.1672- 5131.2018.06.031
前言
宫颈癌是仅次于乳腺癌和结、直肠癌的恶性肿瘤,发病率高,研 究数据表明,全球每年宫颈癌新发患者人数超过50万,其中大部分在 发展中国家,我国每年宫颈癌新发病例人数高达13.16万,占据全球 新发病例的26.3%,且呈现明显地区差异,农村高于城市[1]。近年来, 随着宫颈癌筛查和诊断技术不断发展,宫颈癌总体发病率呈现下降趋 势,但患者发病年龄表现出年轻化趋势,因此,临床上需要一种能够 及时对肿瘤进行诊断的检查方法,这对于制定治疗方案和预后评估具 有重要作用[2]。目前,宫颈癌的临床诊断主要根据妇科检查及组织病 理检查,其分期及治疗主要以国际妇产科联盟(FIGO)系统为临床分期 标准,但大多具有明显主观性和局限性,同时在评估肿瘤的宫旁浸润 及淋巴结转移方面存在严重不足[3]。近年来,随着医学影像学技术的 飞速发展,特别是核磁共振成像(MRI)具有较高的组织分辨率,通过多 序列成像,根据组织间不同信号差异,能够清楚显示盆腔中肿瘤组织 侵犯程度和范围,使得其在宫颈癌诊断中逐渐受到重视[4]。本研究通 过探讨MRI表现与肿瘤对周围组织侵犯程度和范围、淋巴结转移及术前 MRI分期与术后病理分期是否存在一致性,评价MRI对宫颈癌术前病情 评估中的诊断价值,旨在为临床制定和调整治疗方案提供客观依据, 现报道如下。
中国CT和MRI杂志
第16卷, 第 6 期
2018年06月
相关文章