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冠脉CTA在评估糖尿 病患者冠脉临界病 变管腔狭窄程度中 的应用*

作者:王国良 马 光 滕 伟 惠学志

所属单位:河南大学第一附属医院心血管内科 (河南 开封 475000)

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摘要

目的 探究冠脉CT血管造影(CTA) 在评估糖尿病患者冠脉临界病变管腔狭窄 程度中的应用。方法 回顾性分析2016年 5月至2017年5月于我院就诊的经冠状动 脉造影(CAG)检查确诊为冠脉病变临界病 变的62例2型糖尿病患者。所有患者均行 CTA检查,对患者血管狭窄率进行评价, 以CAG所测的狭窄率作为金标准,以50%作 为判断血管狭窄程度的边界值,计算CTA 检测的灵敏度、特异度及准确率,并比较 CTA与CAG测量结果的一致性。结果 CTA评 估冠脉临界病变的灵敏度为90.80%,特 异度为88.89%,阳性预测值为79.79%,阴 性预测值为95.23%,准确率为89.51%, CTA与CAG在冠状动脉狭窄性病变的诊断上 具有较好的一致性(Kappa=0.769)。结论 CTA在评估糖尿病患者冠脉临界病变管腔 狭窄程度时有较高的特异度、灵敏度、阴 性预测值及准确性,临床上可用于糖尿病 患者冠脉临界病变管腔狭窄程度检查。

Objective To explore the application of coronary CT angiography (CTA) in assessing the degree of luminal stenosis of coronary intermediate lesions in patients with diabetes. Methods A retrospective analysis was performed in 62 patients with type 2 diabetes mellitus and coronary intermediate lesions diagnosed by coronary angiography (CAG) who were admitted to the hospital from May 2016 to May 2017. All patients were examined by CTA, and the vascular stenosis rate was evaluated. With the stenosis rate measured by CAG as the golden standard, and 50% as the boundary value to judge the degree of vascular stenosis, the sensitivity, specificity and accuracy of CTA were calculated. The consistency of results of CTA and CAG was compared. Results The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of CTA in assessing coronary artery stenosis were 90.80%, 88.89%, 79.79%, 95.23% and 89.51%, respectively. There was a good consistency between CTA and CAG in the diagnosis of coronary artery stenosis (Kappa=0.769). Conclusion The specificity, sensitivity, negative predictive value and accuracy of CTA are high in evaluating the severity of luminal stenosis of coronary intermediate lesions. It can be used for detecting the severity of luminal stenosis of coronary intermediate lesions in patients with diabetes.

【关键词】冠脉CT血管造影;糖尿病;冠 脉临界病变;管腔狭窄程度

【中图分类号】R587.1

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2018.06.003

前言

在心血管病的临床研究中,将血管造影测定的冠脉狭窄程度 50~70%的病变称为冠状动脉临界病变,这种病变是动脉粥样硬化的特 定发展阶段[1]。研究表明,2型糖尿病是引起动脉粥样硬化及动脉狭窄 性病变的独立危险因素之一,糖尿病心脑血管疾病是糖尿病患者主要 并发症和死亡的主要原因[2],做好糖尿病患者心脑血管疾病的早期诊 断及治疗对患者生存率及预后意义重大。目前,临床上对冠状病变的 诊断方法主要是冠状动脉造影(CAG),这种方法诊断结果虽较为准确, 但其为有创检查且价格昂贵,具有一定的风险[3-4]。近年来,多层螺旋 CT的发展,使得无创性冠状动脉成像成为可能[5]。本研究采用冠脉CT 血管造影(CTA)检测糖尿病患者冠状临界病变,并与CAG诊断结果进行 比较,分析其准确性、灵敏度和特异度,评估冠脉CTA在检查冠状临界 病变的应用价值。现报道如下。