目的 探究弥散张量成像(DTI) 在帕金森(PD)患者诊断中的应用价值。 方法 收集2013年1月-2017年12月我院就 诊的62例PD患者的临床资料为PD组进行 回顾性分析，另选取同期我院体检正常 的62例健康志愿者为对照组，行常规头 部MRI平扫及DTI检查，比较两组黑质、 红核、苍白球、壳核、尾状核、丘脑、 额叶白质各兴趣区的各向异性分数(FA 值)及表观扩散系数(ADC值)。结果 PD组 黑质、壳核的FA值显著低于对照组，差 异有统计学意义(P<0.05)，PD组红核、 苍白球、尾状核、丘脑、额叶白质兴趣 区的FA值与对照组比较，差异无统计学 意义(P<0.05)；PD组黑质、红核、苍白 球、壳核、尾状核、丘脑、额叶白质各 兴趣区ADC值与对照组比较，差异无统计 学意义(P<0.05)。结论 黑质、壳核的FA 值有助于PD的诊断，DTI检查可为PD的病 理机制及早期诊断提供有价值的客观依 据。

Objective To explore the application values of diffusion tensor imaging (DTI) in the diagnosis of patients with Parkinson's disease (PD). Methods The clinical data of 62 PD patients (the PD group) treated in our hospital from January 2013 to December 2017 were retrospectively analyzed, and another 62 healthy volunteers with normal physical examination in our hospital during the same period were selected as the control group, and the two groups were given MRI plain scan and DTI check. The fractional anisotropy (FA values) and apparent diffusion coefficients (ADC values) of regions of interest such as substantia nigra, red nucleus, globus pallidus, putamen, caudate nucleus, thalamus and frontal white matter were compared between the two groups. Results The FA values of the substantia nigra and putamen in the PD group were significantly lower than those in the control group (P<0.05), and there was no significant difference in the FA values of regions of interest such as the red nucleus, globus pallidus, caudate nucleus, thalamus and frontal white matter between the PD group and the control group (P<0.05). There was no significant difference in the ADC values of substantia nigra, red nucleus, globus pallidus, putamen, caudate nucleus, thalamus and frontal white matter between the PD group and the control group (P<0.05). Conclusion The FA values of substantia nigra and putamen are helpful for the diagnosis of PD. DTI examination can provide a valuable objective basis for the pathological mechanism and early diagnosis of PD.