目的 应用64排CTP技术观察米诺 环素在活体兔脑缺血再灌注效果对比分析 研究。方法 选取雄性新西兰白兔50只， 随机分为实验组及对照组，实验组缺血再 灌注前后分别给予米诺环素治疗，分析米 诺环素治疗活体兔脑缺血再灌注组与对照 组CTP的脑血流灌注图、脑血容积图、血 流灌注峰值时间图及功能图像差异性及 TTC染色结果对比分析。结果 脑缺血模型 CTP与病理对照：在缺血不同时间段，CBF 图与MTT图的缺损面积间比较无显著差异 (P>0.05)；CVB图缺损面积与TTB染色缺损 面积在缺血不同时间段之间比较无明显差 异(P>0.05)；在缺血2h组，CBF、MTT图与 CBV图缺损面积、TTC染色缺损面积组之间 比较有显著差异(P<0.05)；在缺血6h组无 显著差异(P>0.05)。活体兔脑缺血再灌注 用米诺环素治疗后脑缺血容积减少且具有 统计学意义(P<0.05)。结论 米诺环素能 够改善由缺血再灌注引起的损伤，同时使 用CTP成像评估活体兔血流改变准确、可 靠，因此，应用64排CTP观察米诺环素对 活体兔脑缺血再灌注效果良好、准确，值 得临床实践应用。

Objective Comparative analysis of the effect of minocycline on cerebral ischemia -reperfusion in vivo rabbits by 64 - row CTP technique. Methods Fifty male New Zealand white rabbits were randomly divided into experimental group and control group, the rats in the experimental group were treated with minocycline before and after ischemia and reperfusion, and to analyze the difference of cerebral blood flow perfusion, cerebral blood volume, blood flow perfusion peak time and functional image difference and TTC staining in cerebral ischemia reperfusion group and control group. Results There was no significant difference between the CBF map and the defect area of the MTF map (P>0.05). There was no significant difference between the defective area of CVB and the defect area of TTB staining in different time periods (P<0.05). There was no significant difference between the two groups (P>0.05). There was no significant difference between the two groups (P>0.05). There was no significant difference between the two groups (P>0.05) No significant difference (P>0.05). The cerebral ischemic volume of the rabbits after cerebral ischemia and reperfusion was decreased and the significance was statistically significant (P<0.05). Conclusion Minocycline can improve the damage caused by ischemiareperfusion, and use CTP imaging to evaluate the accuracy and reliability of living rabbit blood flow changes. Therefore, 64-row CTP observation of minocycline can improve the cerebral ischemia-reperfusion in vivo, accurate, and worthy of clinical practice.