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MRI与血清肿瘤标 志物联合诊断子宫 内膜癌的临床价值

作者:唐上坤 张效杰 肖 华 黄博渊 温小飞

所属单位:广东省阳江市阳春市中医院放射科 (广东 阳江 529600)

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摘要

目的 探讨MRI联合血清肿瘤标 志物用于临床诊断子宫内膜癌患者的价 值。方法 收集我院2014年3月-2016年11 月90例经手术组织病理学确诊为I-II期 子宫内膜癌患者为此次研究对象,对比 MRI联合血清肿瘤标志物与单独运用MRI 检查对子宫内膜癌患者诊断效能差别。 结果 单纯MRI检查敏感度为84.96%、 特异度为70.68%,MRI联合血清肿瘤标 志物检查敏感度为86.72%、特异度为 79.92%,两组间比较,P<0.05;MRI联合 血清肿瘤标志物检查的敏感度明显高于 单纯MRI检查,P<0.05。结论 联合MRI与 血清肿瘤标志物有助提高对早期子宫内 膜癌的诊断率,从而可为临床及时治疗 与正确选择治疗方案提供参考。

Objective To explore the value of MRI combined with serum tumor markers in the clinical diagnosis of endometrial cancer. Methods A total of 90 patients with stage I~II endometrial carcinoma diagnosed by surgical histopathology in November 2016 to March 2014 were collected as the research objects,and com-pare the diagnostic efficacy of MRI combined with serum tumor markers (serum CA125, OPN and CA199) and MRI examination alone in patients with endometrial cancer. Results The diagnostic sensitivity of simple MRI examination was 84.96%, and the specificity was 70.68%. The diagnostic sensitivity of MRI combined with se-rum tumor markers was 86.72%, and the specificity was 79.92%, P<0.05, significantly higher than that of simple MRI examination (P<0.05). Conclusion The combination of MRI and serum tumor markers helps to improve the diagnostic rate of early endo-metrial cancer, which can provide a reference for clinical timely treatment and the correct choice of treatment programs,and it can provide reference for the timely treatment and the correct choice of the treatment plan.

【关键词】血清肿瘤标志物;磁共振; 子宫内膜癌;诊断

【中图分类号】R737.33

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2018.03.026

前言

子宫内膜癌是主要发生于女性子宫内膜上皮细胞的恶性肿瘤,该 疾病早期缺乏特异性的临床症状,当患者确诊时大多已处于疾病中晚 期,此时预后较差,给患者生命及日常生活造成不良影响,甚至给家 庭带来极大经济负担[1-2]。目前临床主要采用手术治疗,术前准确分期 对患者临床治疗及预后具有重要作用。有研究发现,血清中糖类抗原 125(CA125)、骨桥蛋白(OPN)及糖类抗原199(CA199)等指标的升高能 提示女性生殖系统恶性肿瘤可能,但不能明确肿瘤性质和分期;众多 影像学检查方式中,MRI检查具有较好的软组织分辨率,深受临床重 视[3]。本文联合MRI与血清肿瘤标志物用于临床诊断子宫内膜癌,旨在 提高子宫内膜癌患者临床诊断正确率,为患者临床治疗及预后改善提 供帮助。