目的 探讨肝细胞癌普美显(GdEOB-DTPA)MRI增强成像与病理分级的相 关性。方法 对20位患者的25个肝细胞癌 灶进行回顾性分析。所有病例均行MRI 平扫、普美显动态增强扫描及肝胆期扫 描，根据肝胆期病灶的信号强度分为三 组：低信号、混杂信号和等信号，并与 术后标本的病理分级进行对比、分析。 结果 25例肝细胞癌肝胆期的信号强度与 病理分级间有显著的差异。肿瘤的大小 与病理分级无明显差异。结论 肝细胞癌 的普美显MRI增强成像肝胆期信号强度与 病理分级存在明显的相关性，可据此初 步判断HCC的病理分级。建议临床怀疑肝 细胞癌的病人影像检查中选择应用普美 显行MRI增强检查。

Objective To investigate the Correlation of Gd-EOB-DTPA-enhanced MRI with Pathologic Grading in Hepatocellular Carcinoma. Methods Twenty patients with twenty-five hepatocellular lesions were evaluated retrospectively. All of the patients had MRI scan, Gd-EOB-DTPA dynamic enhanced scan and hepatobiliary stage enhanced scan.Hepatobiliary phase images on Gd-EOB-DTPA -enhanced MRI were classified into 3 groups: low, mixed signal or iso. Furthermore, correlations between MRI findings and pathological grade for each hepatocellular lesions were performed and statistically evaluated. Results There was a significant correlation between pathological grade and signal intensity in the hepatobiliary phase in 25 cases of hepatocellular carcinoma. There was no significant correlation between the size of the tumor and the pathological grade. Conclusion Signal intensity in the hepatobiliary phase correlated with histological grade. We may have a new way to preliminary judge the pathological grade of HCC according to Gd-EOB-DTPA-enhanced MRI. Gd-EOB-DTPA-enhanced MRI is recommended to apply in patients who were suspected with hepatocellular carcinoma .