目的 探讨双源CT冠状动脉成 像对于评价冠状动脉临界病变的临床价 值。方法 搜集33例(共41个冠状动脉病 变)行双源CT冠状动脉成像诊断为临界 病变的患者，所有患者均于一周内经冠 状动脉造影证实，并行血流储备分数 (FFR)检测。将41个冠状动脉临界病变按 FFR检测值分为FFR?0.80组和FFR≥0.80 组；分析双源CT冠状动脉成像两组间斑 块负荷和血管重构指数的差异，及其与 FFR检测值的相关性。结果 FFR<0.80组 与FFR≥0.80组血管重构指数有明显统 计学差异(F=16.45,P<0.05)，两组间 斑块负荷无明显统计学差异 ( F = 0 . 5 3 , P>0.05），FFR与RI之间显著正相关 (r=0.502,P>0.05)。结论 双源CT冠状动 脉成像评价临界病变血管重构可能提示 血流动力学变化。应用双源CT冠状动脉 成像评价冠状动脉临界病变有助于临床 制定治疗决策。

Objective To investigate the clinical value of dual-source CT in the evaluation of cononary intermediate lesion. Methods 33 cases (41 sites) of coronary intermediate lesions underwent dual-source CT coronary angiography and were confirmed by conventional coronary angiography and Fractional Flow Reserve(FFR) test within one week. According to FFR value, 41 intermediate lesions were divided into two groups: FFR<0.80 group and FFR≥0.80 group. The differences between two groups in plaque burden and vascular remodeling index and the correlation of those parameters with FFR value were analyzed. Results There was statistically significant difference in vascular remolding index between two groups (F=16.45, P<0.05). There was no statistically significant difference in plaque burden between two groups(F=0.53, P>0.05). There was a significant positive correlation between FFR value and RI(r=0.502, P>0.05). Conclusion Dual-source CT coronary angiography may suggest hemodynamic changes of intermediate lesion by evaluating vascular remodeling, and could be helpful in clinical decision-making.