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MRI化学位移成像诊断肾上腺腺瘤的研究*

作者:卢壬肖 刘建平 李耀平

所属单位:广东省茂名市高州市中医院(广东 茂名 525200)

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摘要

目的 探析MRI化学位移成像在肾 上腺腺瘤患者临床诊断中的应用价值。方 法 选择我院2010年1月-2015年9月期间收 治110例肾上腺腺瘤疑似患者作为研究对 象,均应用超导型1.5T磁共振机对患者 进行MRI检查。明确MRI化学位移成像中非 肾上腺腺瘤患者及肾上腺腺瘤患者ALR、 ASR及AWR值的差异。结果 110例行MRI检 查病例中,46例为肾上腺腺瘤(22例为无 功能腺瘤、24例为功能性腺瘤)。病变以 圆形或椭圆为主、边界清晰、与正常肾上 腺相连,T1WI上信号强度较均匀。46例腺 瘤患者中,16例患者的反相位上呈现信号 减低、24例呈现部分减低、6例无明显改 变。非腺瘤病灶ALR值均在0.77以上,腺 瘤病灶多低于0.63;非腺瘤患者ASR值均 超过0.73、腺瘤病灶多低于0.59;非腺瘤 病灶AWR值均超过0.78,腺瘤病灶多低于 0.65。两组病灶ALR、ASR及AWR中位值的 差异有统计学意义(P<0.05)。结论 MRI 化学位移成像技术在肾上腺腺瘤临床诊 断中的应用可实现有效定性诊断,借助 LAR、LSR、LWR值可取得较高敏感性,具 有较大借鉴价值,值得参考。

Objective To explore the application value of MRI chemical shift imaging in the clinical diagnosis of adrenal adenomas. Methods 110 patients with adrenal adenomas treated from January 2010 to September 2015 were treated as the research objects and MRI was performed in all patients with superconduct 1.5T magnetic resonance machine. Differences of ALR, ASR and AWR values in MRI chemical shift imaging between patients with non-adrenal adenomas and patients with adrenal adenomas. Results Among the 110 cases who underwent MRI examination, 46 cases were with adrenal adenomas (22 cases of non-functional adenomas, 24 cases of functional adenomas). The lesions were mainly round or oval and the boundaries were clear and were connected with the normal adrenal gland. The signal strength on T1WI was relatively homogeneous. In 46 patients with adenomas, 16 patients showed signal decrease in antiphase, 24 cases showed partial reduction and 6 cases had no obvious changes. The ALR values of the non-adenomas were above 0.77 while of adenoma lesions were lower than 0.63; The ASR values of non-adenomas were above 0.73 while of adenoma lesions were lower than 0.59; The AWR values of non-adenoma lesions were above 0.78 while of adenoma lesions were lower than 0.65. There were statistically significant differences in the median values of ALR, ASR and AWR between the two groups (P<0.05). Conclusion The application of MRI chemical shift imaging in clinical diagnosis of adrenal adenomas can achieve effective qualitative diagnosis. With the help of LAR, LSR and LWR values, higher sensitivity can be obtained and it is of great reference value.

【关键词】肾上腺腺瘤;MRI;化学位移 成像;脂肪;相位

【中图分类号】R736.6

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2017.06.031

前言

肾上腺腺瘤包括肾上腺皮质腺瘤与肾上腺髓质腺瘤两种,其中 肾上腺皮质腺瘤更为多见,且以单侧单发性为主,直径在1~5cm之 间[1]。可分为功能性与无功能性两种。其中前者易引起Cushing综合征 或醛固酮增多症,临床表现为水牛背、满月脸等。肾上腺腺瘤虽为良 性,但尽早确诊并予以手术利于症状改善。由于肾上腺腺瘤细胞内多 含有脂质,因而其CT及MRI影像资料具有一定特征性[2],易于诊断。需 引起注意的是,肾上腺为恶性肿瘤转移好发部位[3],因此积极对肾上 腺占位性病变进行定性诊断具有重大意义。本文以我院收治我院2010 年1月~2015年11月期间收治110例肾上腺腺瘤疑似患者为例,探析MRI 化学位移成像在肾上腺腺瘤患者临床诊断中的应用价值,现报道如 下。