目的 探讨MRI对儿童癫痫患者海 马硬化的应用价值分析。方法 选取2013 年11月-2014年11月经手术治疗确诊的癫 痫海马硬化患者23例，通过对23例儿童 癫痫海马硬化患者进行磁共振成像常规 MRI扫描、液体衰减反转恢复序列(fluid attenuated inversion recovery， FLAIR)薄层扫描、辅助T2W-FLAIR序列、 横断位GM-only、三维T1加权成像(3DT1W) 与海马单体素磁共振波谱成像(1 H-MRS)， 分析MRI检查对癫痫患者海马硬化的应用 价值。结果 MRI检查显示海马结构特征清 晰，23例患者在FSET1WI序列图像中海马 面积均有萎缩性改变；20例患者出现单侧 海马体积缩小(左侧11例，右侧9例)；3 例患者出现海马体积双侧缩小；FLAIR序 列中23例患者海马病变处信号均增高， FSET2WI序列19例患者病变侧海马信号增 高，4例无明显变化；海马病变侧头部浅 沟明显消失20个，病变侧白质萎缩3个， 病变侧颞角增大1个，病变侧颞叶萎缩2 个；海马硬化在MRI图像中以表面硬化、 颞角增大、T2WI序列中海马信号异常升 高、海马体积缩小、病变侧NAA峰下降等 为主要特征。结论 MRI各序列的扫描图像 对海马硬化区域显示直观，可定量分析脑 组织内生化代谢的异常变化，可对深入的 了解癫痫灶的病理生理改变及临床手术定 位提供丰富的影像学资料。

Objective To investigate the application value analysis of MRI on hippocampal sclerosis of epileptic. Methods 23 cases with hippocampal sclerosis in our hospital from November 2013 to November 2014 were selected and were given MRI scan, FLAIR thin slice scan, T2W-FLAIR sequence, Travers GM-only, 3DT1W and 1H- MRS, analyze the application effect of MRI on hippocampal sclerosis of epileptic. Results MRI showed that hippocampal formation is clear, 23 cases on FSET1WI all had shrink hippocampus area, 20 cases showed unilateral hippocampus volum shrink (left side 11 cases, right side 9 cases), 3 cases showed hippocampus volum both sides shrink. In FLAIR sequence, 23 cases showed increased signal at hippocampal abnormality, in FSET2WI sequence, 19 cases showed increased signal at hippocampal abnormality, 4 cases had no obvious changes, 20 cases of head shallow ridges obvious disappear, 3 white matter atrophy, 1 temporal Angle enlargement, 2 temporal lobe shrink; In MRI image, hippocampal sclerosis showed surface hardening, temporal Angle enlargement, hippocampal signal abnormity elevator, hippocampus volum shirink, NAA declination. Conclusion MRI shows clear scan image of hippocampal sclerosis area, it can analyze anomalous change of biochemical metabolism and provide image data for clinical surgical positioning.