目的 探讨肿瘤标记物联合多 层螺旋CT诊断早期肺癌的临床价值。方 法 选择我院2012年3月至2016年3月期间 收治的62例肺癌患者作为研究对象，患 者均行肿瘤标志物检测及螺旋CT检查， 总结SQC、ADC、SCLC等不同类型肺癌的 螺旋CT征象特点，分别计算肿瘤标志物 诊断肺癌的敏感性及联合诊断的敏感 性。结果 SQC的Cyfra21-1诊断符合率 最高，为71.4%(20/28)；ADC的CEA诊断 符合率最高，为70.8%(17/24)；SCLC的 NSE诊断符合率最高,为70.0%(7/10)。 肿瘤标记物联合诊断肺癌的符合率为 80.6%(50/62)，肿瘤标志物与螺旋CT联 合诊断肺癌的符合率为93.5%(58/62)， 差异有统计学意义(χ 2 =4.593， P=0.032)。结论 肿瘤标记物联合多层 螺旋CT诊断早期肺癌具有更高诊断符合 率，具有良好临床应用价值。

Objective To investigate the clinical value of tumor marker combined with multi-slice spiral CT in the diagnosis of early lung cancer. Methods Sixty-two patients with lung cancer admitted to our hospital between March 2012 and March 2016 were selected as the study subjects. The tumor marker detection and spiral CT examination were performed. The spiral CT features of SQC, ADC, SCLC and other types of lung cancer were summarized. The sensitivities of tumor markers and the combined diagnosis of lung cancer were calculated respectively. Results The coincidence rate of Cyfra21-1 in the diagnosis of SQC was the highest, which was 71.4% (20/28). The coincidence rate of CEA in the diagnosis of ADC was the highest, which was 70.8% (17/24); The coincidence rate of NSE in the diagnosis of SCLC was the highest, which was 70% (7/10). The coincidence rate of combined diagnosis of tumor markers was 80.6% (50/62) while the coincidence rate of tumor markers combined with spiral CT in the diagnosis of lung cancer was 93.5% (58/62) (χ2 =4.593, P=0.032). Conclusion The coincidence rate of tumor markers combined with multi-slice spiral CT in the diagnosis of early lung cancer is high, with high clinical application value.