目的 探讨青年人和老年人急性 脑梗死代谢物N-乙酰天门冬氨酸(NAA)、 胆碱(Cho)乳酸(Lac)等的差异性。方法 对24例青年人和27例老年人急性脑梗死发 病后6-24小时内病灶及自身镜像区行1HMRS采集NAA、Cho、Lac等代谢物波谱曲 线，观察各代谢物变化，比较及分析组 间峰值的差异性。结果 青年组和老年组 NAA均有不同程度下降，均出现Lac倒置双 峰、Cho峰以降低为主，多变；与镜像组 比较NAA、Cho、Lac均有显著性差异。不 同年龄段急性脑梗死NAA和Cho改变有显著 性差异，Lac无显著性差异。结论 NAA、 Lac是脑梗死早期敏感的标记物；Cho辅助 补充代谢信息。NAA和Cho变化特征与年龄 等有一定的相关性，Lac则无。应重视不 同年龄段脑梗死代谢状况的差异性。

Objective To study the differences of the peak of NAA, Cho and Lac between the young patients and the elderly with acute cerebral infarction. Methods Spectral curves of metabolites including NAA, Cho, Lac and so on were collected, which were in the lesion and its mirror region of 24 young patients and 27 the elderly cases with cerebral infarction occurred in 6-24 hours. The changes in spectral curves of metabolites were observed. The comparative analysis of differences was carried out between the groups. Results The NAA peaks were decreased in varying degrees, that of Lac were increased and two-inverted-peak of Lac with the different peak could be seen. The peaks of Cho were changeable, overall decreased and with uncertainty. There were significant differences (P<0.05) between the infarction group and the mirror region in the young. And so were the elderly. There were significant differences (P<0.05) in the changes of metabolites NAA or Cho between the young and the elderly with infarction. There was no significant difference (P>0.05) in the change of Lac. Conclusion NAA and Lac was the sensitive indicator of acute cerebral infarction, Cho could also provide useful information about the relevant metabolism situation. There is a certain correlation between the change characteristics of NAA or Cho and age. But that of Lac was no. So it should pay attention to the differences in the metabolic status of the cerebral infarction in different age.