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MR弥散加权成像参数与宫颈癌肿瘤细胞组织学特点的相关性研究

作者:陈艳霞1 李和平2

所属单位:1.新疆医科大学第一附属医院妇科 (新疆 乌鲁木齐 830054) 2.新疆库尔勒市解放军第273医院 普外科 (新疆 乌鲁木齐 830054)

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摘要

目的 研究MR弥散加权成像参数 与宫颈癌肿瘤细胞组织学特点之间的相 关性。方法 临床纳入60例我院2014年1 月-2015年12月期间收治的宫颈癌患者, 均行MR弥散加权成像(DWI)临床检查,分 析评价系数ADC值与分化程度及肿瘤细胞 间质比例、病理类型等肿瘤细胞组织学 特点间的相关性。结果 宫颈癌患者ADC值 与肿瘤细胞间质比例、分化程度呈现一定 负相关性,而与病理类型呈现一定正相关 性(P<0.05);宫颈鳞癌组患者的ADC值较 宫颈腺癌组显著要低,高分化组患者ADC 值较低分化组患者显著要低(均P<0.05); 肿瘤细胞间质比例≧70%组患者的ADC值显 著低于肿瘤细胞间质比例<70%组,差异 具有统计学意义(P<0.01)。结论 宫颈癌 肿瘤细胞组织学特点与MR弥散加权成像 (DWI)参数关系密切,可成为临床评估宫 颈癌预后、制定治疗方案的重要基础依 据。

Objective To study the MR diffusion weighted imaging parameters and cervical cancer tumor cells of the correlation between histological characteristics. Methods Clinical in 60 cases of cervical cancer patients admitted in our hospital during 2014.1 2015.12, all lines of MR diffusion weighted imaging (DWI) can clinical examination, analysis and evaluation coefficient of ADC values and the differentiation degree and the proportion of stromal tumor cells, pathological type and so on correlation between the histological characteristics of tumor cells. Results In patients with cervical cancer ADC values between tumor cells and mass ratio, degree of differentiation of present certain negative correlations, and characteristic to some positive correlation with pathological type (P<0.05). Cervical squamous carcinoma patients the ADC values of the cervical adenocarcinoma group was significantly lower, ADC values in patients with well-differentiated group patients was significantly lower in the poorly differentiated group (all P<0.05). Tumor cells interstitial ≧ 70% group of ADC values significantly lower than that of tumor cells in patients with interstitial proportion < 70% group, the difference statistically significant (P<0.01). Conclusions Cervical cancer tumor cells histological characteristics and parameters of MR diffusion weighted imaging (DWI) can close, can be a clinical evaluation of prognosis of cervical cancer, to develop the important basis for basis of treatment.

【关键词】宫颈癌;肿瘤细胞组织学特点;磁共振成像

【中图分类号】R445.2;R737.33

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2016.06.032

前言

宫颈癌是临床妇科中常见的恶性肿瘤,发病率较高,危害程度较 大,危及了女性的生命安全。有研究表明,临床通过磁共振成像检查 对宫颈癌的诊断和治疗提供了重要依据,但常规MRI成像效果欠佳。近 些年,MR弥散成像应用于临床检查中,为宫颈癌的早期诊断、鉴别及 分期提供了一定的理论依据[1]。同时,有资料显示,MR弥散成像在宫 颈癌的预后评估方面也起到了重要的指导作用。然而,目前鲜有报道 研究MR弥散成像参数与宫颈癌肿瘤细胞组织学特点间的关系,这使得 临床评估宫颈癌预后和治疗方案存在一定的不足。故本次研究探讨MR 弥散加权成像参数与宫颈癌肿瘤组织学特点的相关性,现报道如下。