目的 探讨MRI不同序列扫描 在新生儿缺氧缺血性脑损伤(HIE)诊断 的应用情况。方法 回顾性分析32例 临床确诊为HIE患儿的MRI图像，采用 常规磁共振图像(MRI)、弥散加权成像 (DWI)及其表观弥散系数值(ADC)、磁敏 感加权成像(SWI)扫描，评估不同扫描 序列在HIE诊断中的应用。结果 常规 MRI+SWI+DWI诊断HIE的阳性率为90.63% 显著高于常规MRI+SWI(65.63%)、常规 MRI+DWI(59.38%)、常规MRI(43.75%)(P ＜0.05)。常规MRI共检出12例为HIE，其 中5例T1高信号；8例T2高信号，灰白质 无清晰界限；常规MRI+DWI检出19例为 HIE，其中10例基底节区、丘脑等部位在 DWI图上为高信号，呈片状分布，ADC图像 上表现为信号减低。常规MRI+DWI+SWI共 检出21例HIE，其中16例在SWI图像呈扇 形、斑点状及斑片状分布的低信号。结论 MRI+SWI+DWI序列联合扫描可提高HIE诊断 准确率。

Objective To investigate the application of different sequence scan of MRI in the diagnosis of neonatal hypoxic ischemic encephalopathy (HIE). Methods The MRI images of 32 children with clinically diagnosed HIE were retrospectively analyzed. Conventional magnetic resonance imaging (MRI), diffusion weighted imaging (DWI) and its apparent diffusion coefficient (ADC) and magnetic susceptibility weighted imaging (SWI) can were used to evaluate the application of different scanning sequences in the diagnosis of HIE. Results The positive rate of conventional MRI+SWI+DWI in the diagnosis of HIE (90.63%) was significantly higher than that of conventional MRI+SWI (65.63%), conventional MRI+DWI (59.38%) and conventional MRI (43.75%) (P＜0.05). 12 cases of HIE were detected by conventional MRI, including 5 cases showing T1 high signal. 8 cases showing T2 high signal and cinereum matter was without clear boundaries. 19 cases with HIE were detected by MRI+DWI, including 10 cases of basal ganglia, thalamus and other areas showing high signal on DWI images, patchy in distribution and signal decline on ADC images. 21 cases of HIE were detected by conventional MRI+DWI+SWI, including 16 cases showing low signal, the SWI images showed a fanshaped, spot-like and patchy in distribution on SWI images. Conclusion The combined MRI+SWI+DWI sequence can improve the diagnostic accuracy of HIE.