目的 研究宫颈癌放化疗前后CT 灌注参数变化对放化疗敏感性的评估价 值。方法 对我院59例宫颈癌放疗患者分 别进行CT平扫及增强扫描，将59例患者 根据临床疗效分为CR组(27例)、PR组(16 例)、SD组(10例)、PD组(6例)，比较以上 四组不同疗效患者的CT灌注参数差异， 包括血流量(BF)、血容量(BV)、平均通过 时间(MTT)、表面通透性(PS)，以评价CT 灌注参数变化用于宫颈癌放化疗敏感性 评估的可行性。结果 四组患者BF、MTT 比较无统计学意义(F=0.412，F=1.360， P＞0.05)，BV、PS比较有统计学意义 (F=71.264，F=25.635，P＜0.05)，疗效 越好则BV、PS值越高，CR、PR组BV值显著 高于SD、PD组，CR高于PR，SD、PD组比较 无统计学意义(P＞0.05)，PS随疗效变差 呈递减趋势，组间比较均有统计学意义(P ＜0.05)；结论 CT灌注参数血容量以及表 面通透性可实现宫颈癌放化疗敏感性的评 价以及疗效评估，为放化疗治疗方式的选 择及预后判断有重要的指导价值。

Objective To study the changes value of CT perfusion parameters in the evaluation of sensitivity before and after radiotherapy and chemotherapy of cervical cancer. Methods 59 patients with cervical cancer treated with radiotherapy in our hopsital underwent CT plain and enhanced scan. According to the curative effect, the patients were divided into CR group (27 cases), PR group (16 cases), SD group (10 cases) and PD group (6 cases). The differences of CT perfusion parameters of patients with different curative effects in the four groups were compared, including blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS) to evaluate the feasibility of applying changes of CT perfusion parameters in the evaluation of the sensitivity to radiotherapy and chemotherapy of cervical cancer. Results The differences in BF and MTT between the four groups were not statistically significant (F=0.412, F=1.360, P＞0.05) while in BV and PS were statistically significant (F=71.264, F=25.635, P＜0.05). The better the curative effect was, the higher the BV and PS values were. BV values of CR and PR group were significantly higher than those of SD and PD group and CR was higher than PR. The differences between SD and PD group were not statistically significant (P＞0.05); With the deterioration of curative effect, PS decreased. The differences between groups were statistically significant (P＜0.05). Conclusion CT perfusion parameters, blood volume and permeability surface can be used to evaluate the sensitivity of radiotherapy and chemotherapy of cervical cancer and they are of guidance value in the selection of treatment method and judgement of prognosis