目的通过分析磁共振弥散张量 成像(DTI)联合1H磁共振波谱(1H-MRS)应 用于新生儿缺氧缺血性脑病(HIE)中诊断 效果，从而为临床HIE患者准确诊断提供 参考。方法 选取本院90例HIE患儿作为本 次研究观察组，另选取同期正常分娩的90 例健康新生儿为研究对照组。两组均采 用1H-MRS及DTI扫描检查，并比较两组影 像学图像，测定两组胆碱复合物(Cho)、 N-乙酰基天门冬氨酸(NAA)、肌酸复合物 (Cr)、乳酸(LAC)、肌醇(MI)、谷氨酸及 谷氨酰胺(Glu-Gln)等代谢产物，然后进 行比较。结果 经检查发现，其中对照组 未见DTI异常信号；观察组中，采用DTI检 出HIE者为76例，诊断准确率为84.4%明显 高于普通MRI检出39例，占43.3%，具有 统计学意义，P<0.05。观察组患儿NAA/ Cr明显低于对照组，而Cho/Cr、MI/Cr及 Clu+Cln/Cr、Lac/Cr明显高于对照组，差 异具有显著性，P<0.05。结论 临床应用 DTI可于HIE早期检测中有效显示其病灶范 围及数目，同时采用1H-MRS可无创地测量 患儿脑部组织缺氧、缺血过程中所产生的 代谢产物，两者结合可提高患儿临床诊断 准确性，为患者预后评估提供有力价值。

Objective Through the analysis of diffusion tensor imaging (DTI) combined 1 H magnetic resonance spectroscopy (1H-MRS) in neonatal hypoxic-ischemic encephalopathy (HIE) in the diagnostic results, thus providing an accurate reference for clinical diagnosis in patients with HIE. Methods Select the hospital 90 cases of HIE, as observed in this study group, select another period of 90 cases of normal deliveries healthy newborns in the control group for the study. Both groups were 1 H-MRS and DTI scans and radiographic images were compared, measured two choline (Cho), N-acetyl aspartate (NAA), creatine (Cr), lactate (LAC), myo-inositol (MI), glutamate and glutamine (GluGln) and other metabolites, and then compared. Results The inspection found that one of the control group had no abnormal signal DTI; observation group, using DTI HIE were detected for 76 cases, 84.4% diagnostic accuracy was significantly higher than normal MRI detected in 39 cases (43.3%), a statistically significance, P<0.05. Observation group of children NAA/Cr was significantly lower than the control group, while Cho/Cr, MI/Cr and Clu+Cln/Cr, Lac/Cr was significantly higher, the difference was significant, P<0.05. Conclusion DTI may HIE clinical applications for early detection and effective display of its range and the number of lesions, while using 1 H-MRS can noninvasively measuring brain tissue hypoxia in children, metabolites produced during ischemia, a combination that can increase the risk of children clinical diagnostic accuracy for patients to provide strong prognostic value.