摘要
目的探讨中药疏肝消脂方治疗 非酒精性脂肪肝的疗效及治疗前后肝脏CT 影像学差异。方法 60例确诊为非酒精性 脂肪肝患者随机分为治疗组和对照组, 每组30例,对照组患者给予调节饮食结合 适当运动进行治疗,治疗组在此基础上 服用疏肝消脂方,分析比较治疗后3个月 后两组CT、临床及生化指标变化情况。 结果 治疗组临床治疗总有效率93.33%, 对照组86.67%,两组比较差异有统计学 意义(P<0.05);治疗后,与对照组相 比,治疗组ALT、AST、TC及TG等肝功能各 项指标均有所改善,差异有统计学意义 (P<0.05);与治疗前比较,治疗组肝CT值 及肝/脾CT比值均升高,差异有统计学意 义(P<0.05);治疗后与对照组相比,治疗 组肝CT值及肝/脾CT比值均升高,差异有 统计学意义(P<0.05)。结论 疏肝消脂方 治疗非酒精性脂肪肝疗效显著,CT定量技 术评估中医药治疗非酒精性脂肪肝疗效方 法安全、准确。
Objective To investigate the effect of Shugan Treatment of Nonalcoholic fatty liver and liver CT imaging efficacy differences before and after treatment. Methods 60 cases diagnosed as non-alcoholic fatty liver disease were randomly assigned to a treatment group and a control group of 30 patients, The control group received diet and adequate exercise to adjust for treatment, the treatment group took Shugan Xiaozhi Fang on this basis, Analysied and comparison of the two groups CT, clinical and biochemical indicators of change in three months. Results The treatment group in the total efficiency of 93.33%, 86.67% in the control group, the difference was statistically significant (P <0.05); Compared with the control group, the ALT, AST, TC and TG and other indicators of liver function of treatment group were improved, and the difference was statistically significant (P <0.05); compared with before treatment, the treatment of liver and liver CT value / spleen CT ratio were increased, the difference was statistically significant (P <0.05); After treatment compared with the control group, the treatment of liver and liver CT value / spleen CT ratio were increased, the difference was statistically significant (P <0.05). Conclusion Shugan Xiaozhi Fang treat non-alcoholic fatty liver disease significantly, CT quantitative techniques to assess medical treatment of nonalcoholic fatty liver disease method is safe, accurate.
【关键词】非酒精性脂肪肝;疗效;影像学差异
【中图分类号】R575.5;R445.3
【文献标识码】A
【DOI】10.3969/j.issn.1672-5131.2015.07.023
前言
非酒精性脂肪性肝病(NAFLD)是指除酒精和其他明确的损肝因素所 致的肝脏内脂质代谢紊乱,病理特征是表现为肝细胞脂肪变性和脂肪 蓄积。包括单纯性脂肪肝以及由其演变的脂肪性肝炎(NASH)和肝硬化 [1]。在诊断方面,CT和B超是诊断脂肪肝最为重要的手段,B超检查简单 易行,安全无辐射,经济且具有好的特异性,但CT检查对组织分辨率 高,可准确清晰观察肝脏病灶密度改变并显示其大小、形态、结构等 [2]。对于非酒精性脂肪肝的治疗,包括基础治疗和药物治疗,我们以疏 肝消脂肪方治疗该病,利用CT进行疗效评估,现报告如下。
中国CT和MRI杂志
第13卷, 第 7 期
2015年07月
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