论著-头颈部
CT引导下肺门病变细针穿刺针吸活检与DNA倍体检测联合应用的价值分析*
作者:唐 勇1 曹林德2 杨 鸿2 陈卫平2 杨 文2
所属单位:1.广西桂林市中医医院放射科 2.广西壮族自治区第二人民医院放射科(广西 541002)
PDF摘要
目的研究CT引导下穿刺针吸活 检联合DNA倍体检测应用于肺门病变的临 床诊断价值。方法 选取肺门部病变68 例,行CT引导下穿刺针吸活检联合DNA倍 体检测、CT引导下穿刺针吸活检、DNA倍 体检测。以手术结果(组织病理检查)为标 准对比三种方法诊断准确率。结果 CT引 导下穿刺针吸活检、DNA倍体检测、CT引 导下穿刺针吸活检联合DNA倍体检测诊断 正确率分别为89.71%、88.24%、97.06%, 与前两者比较,后者诊断正确率最高,P <0.05。结论 CT引导下穿刺针吸活检联 合DNA倍体检测弥补了单独使用CT引导下 穿刺针吸活检或DNA倍体检测的不足,显 著提高诊断正确率,为肺门病变治疗方案 提供重要依据,值得推广和应用。
Objective This paper is to investigate clinically diagnostic value of suction biopsy needle under CT in combination with DNA ploidy determination applied to lung door lesions. Methods Sixty eight patients with hilus pulmonis lesions undergoing needle biopsy aspiration combining ploidy DNA determination under CT, needle aspiration biopsy under CT, DNA ploidy determination. Diagnostic accuracy of three methods were compared as surgical results (histopathologic examination) as criterions. Results The diagnostic accuracies of puncture needle biopsy under CT, DNA ploidy determination, needle aspiration biopsy under CT in combination with DNA ploidy determination hit 89.71%, 88.24% and 97.06% respectively, and the diagnostic accuracy of the later one is higher when compared to that of the former one (P < 0.05). Conclusion The puncture needle biopsy under CT in combination with DNA ploidy determination make up for the insufficiency of single application of puncture needle biopsy under CT or DNA ploidy under CT, significantly improving diagnostic accuracy, providing important basis for the lung lesions treatment, and being worthy of popularization and application.
【关键词】DNA倍体检测;CT定位;穿刺针吸活检
【中图分类号】R322.3+5
【文献标识码】A
【DOI】10.3969/j.issn.1672-5131.2015.07.012
前言
肺部是炎症、肿瘤的好发部位,临床上常使用临床体征及症状、 影像学、实验室检查等非入侵性的手段进行诊断,随着科技发展,这 些肺部疾病传统检查手段已经难以满足临床需要。穿刺针吸活检(fine needle aspiration cytology,FNAC)、DNA倍体检测术是目前临床中 肺部疾病主要诊断方法。临床上常在CT引导下进行各种疾病微创治疗 和诊断,CT引导下细针穿刺针吸活检术在肺周围占位疾病诊断中有重 要价值,而使用流式细胞仪(FCM)进行人体肿瘤DNA异倍体测量为恶 性肿瘤诊断的重要方法之一[1]。笔者选取68例肺门病变患者作为研究 对象,将CT引导下FNAC和DNA倍体检测用于肺门病变的诊断,观察二者 合用在肺门病变诊断中的价值,现报道如下。
中国CT和MRI杂志
第13卷, 第 7 期
2015年07月
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