目的探讨手足口病脑炎的MRI特 征表现，以提高对该病MRI表现的认识， 对临床判断病情及治疗预后提供可靠的影 像学依据。方法 对东莞地区127例来我院 就诊的手足口病脑炎患儿进行颅脑MRI扫 描，获取并分析T1WI、T2WI、T2WI/FLAIR 及DWI图像，对病变的信号、部位、形态 及周围水肿情况等进行分析。结果 127例 颅脑MRI扫描中109(86％)例脑实质未见明 确异常信号影，18(14％)例信号有异常表 现：呈斑点、斑片状、片带状T1WI稍低 或等信号，T2WI呈稍高或高信号，T2WI/ FLAIR呈高信号，比T2WI对比明显，病灶 显示更为清楚，DWI呈等或高信号，大部 分病灶边界模糊，考虑为急性期表现，周 围水肿不明显，未见明显占位效应，仅部 分脑干似有增粗，脑室略变窄，其中男 13例，女5例(男女比例约2.6:1)，病变位 于脑干10例，病变累及深部核团、两侧半 卵圆中心及额、顶叶脑白质区8例，位于 小脑1例。结论 手足口病脑炎常单发或多 发累及脑干，信号对比度较低，周围水肿 不明显，MRI表现具有一定特征；T2WI、 T2WI /FLAIR及DWI序列对比度相对较高， 对病变的检出、范围的判断起重要作用。 MRI在手足口病脑炎的诊断、判断预后中 具备明显优势，具有重要的参考意义。

Objective To study the MRI features of hand, foot and mouth disease encephalitis, in order to improve the understanding of MRI manifestation of the disease, the clinical judgment condition and provide reliable imaging based on treatment outcome. Methods One hundredand twenty-seven to our hospital in dongguan area of children with hand, foot and mouth disease encephalitis in craniocerebral MRI scanning, capture and analysis T1WI, T2WI, T2WI/FLAIR and DWI images, can the pathological changes of signal and location, shape and surrounding edema of analysis. Results One hundredand twenty-seven of cerebral MRI scans in 109 (86%) cases of abnormal parenchymal did not see clear signal, 18 (14%) cases of abnormal signal has a performance: spots, patchy slightly low or iso signal, belt-like T1WI, T2WI is slightly high or iso signal, T2WI/FLAIR show high signal, contrasts than T2WI, lesions showed more clear, DWI is iso or high signal, such as most of the lesions, fuzzy boundaries considering for acute stage performance, peripheral edema is not obvious, did not see clearly to take effect, only part of the brain stem with enlargement, ventricle slightly narrowed, including 13 cases of male, female in 5 cases (male to female ratio is about 2.6:1), 10 cases of lesions located in the brain stem, deep lesions involving the nucleus accumbens, on both sides of the half egg circle center and the frontal, parietal area 8 cases of cerebral white matter, is located in the cerebellum in 1 case. Conclusion Hand, foot and mouth disease often single or multiple involving the brain stem encephalitis, signal with low contrast, peripheral edema is not obvious, MRI performance has a certain characteristic; T2WI, T2WI/FLAIR and DWI sequence contrast is relatively high, the lesion detection, scope, judgment plays an important role. MRI in the diagnosis of hand, foot and mouth disease encephalitis, has the obvious advantage in the prognosis, which has important reference meaning.