目的应用4D-THRIVE动态增强 扫描磁共振成像技术，分析宫颈鳞癌微 血管通透性的特点及临床意义。方法 对 30例正常宫颈组及72例宫颈鳞癌组(Ⅱ期 及Ⅲ期分别为44例，28例）分别进行4DTHRIVE动态增强扫描检查，在Matlab平 台下对兴趣区内STC及CTC进行非线性拟 合获得血管通透性相关参数Ktrans，Kep及Ve 值，评估正常宫颈组、宫颈鳞癌Ⅱ期及宫 颈鳞癌Ⅲ期血管通透性的特点。结果 宫 颈鳞癌组与正常宫颈组比较，宫颈鳞癌组 的Ktrans，Kep及Ve值较正常宫颈组显著升高 (P<0.05)；宫颈鳞癌Ⅱ期、Ⅲ期的微血管 参数相比较，Ⅲ期的Ktrans及Kep值较正常宫 颈鳞癌组显著升高(P<0.05)，Ve值无显著 性差异(P>0.05)。结论 MRI动态增强定量 分析微血管通透性可作为宫颈鳞癌临床分 期的有益补充。

Objective To study the cervical squamous cell carcinoma microvascular permeability characteristics and clinical significance by using 4D-THRIVE dynamic contrast-enhanced MRI. Methods The maximal values of Ktrans and Kep and Ve from 72 patients with cervical squamous cell carcinoma (44 with stage II , 28 with stage III ) and 30 with no cervical carcinoma for controlled group were obtained by 4D THRIVE DCEMRI. In Matlab platform interest in the region STC and CTC were obtained nonlinear fitting microvascular permeability parameters Ktrans, Kep and Ve values, assess normal cervix, cervical squamous cell carcinoma II, III characteristics and vascular permeability. Results There were significant differences between the controlled group and patients with cervical squamous cell carcinoma for Ktrans and Kep and Ve (p＜0.05). Significant differences were also obtained between stage II and stage III for Ktrans and Kep(p＜0.05), but for Ve (p＞0.05). Conclusion Our results suggest that microvascular permeability from quantitative analysis of DCE-MRI is helpful for staging cervical squamous cell carcinoma.