论著-头颈部
肾透明细胞癌的CT表现与Ki67、MVD、P73表达的相关性研究*
作者:杨 毅1 周俊林2 郭 玲3 董 驰4
所属单位:1.陕西省咸阳市第一人民医院影像中心(陕西 咸阳 712000) 2.兰州大学第二临床医院放射科(甘肃 兰州 730030)
PDF摘要
目的探讨肾透明细胞癌的CT表 现与Ki67、MVD、P73表达的相关性,通过 CT表现评价其部分生物学行为。方法 分 析经手术病理证实的30例肾透明细胞癌 的CT表现,同时对其进行相关免疫组化染 色,分析肾透明细胞癌的CT表现及其与 MVD、Ki67、P73表达的相关性。结果 肾 透明细胞癌中的囊变坏死、肿瘤边界、最 大强化程度及大小均与Ki67、MVD、P73 表达正相关(P<0.05),肿瘤出血与MVD、 Ki67表达有统计学意义(P<0.05),而与 P73表达无关(P>0.05),钙化与Ki67、 MVD、P73表达无统计学差异(P>0.05)。结 论 1、通过MSCT扫描,可以对肾透明细胞 癌进行比较准确的术前诊断。2、肾透明 细胞癌的部分CT征象与Ki67、MVD、P73的 表达具有相关性,可能在一定程度反映出 肿瘤的生物学特性。
Objective To study the correlation between CT features and the expression of Ki67 and MVD, P73 in clear renal cell carcinoma (CCCRCC). So as to evaluate CT features of CCRCC and its biological behaviour. Methods To analyse the CT features of 30 cases with CCRCC which were confirmed by operation and pathology . The expression of MVD, Ki67, P73 of the collected organic material were confirmed by Immunohistochemical staining.then analized the relationship between CT features and the expression of MVD and Ki67, P73. Results 1,The expression of Ki67, MVD, P73 and MVD of CCRCC are positively related to the tumor boundary, the largest enhanced degree, the biggest tumors size (P<0.05). The positive expression of Ki67 and MVD are related to hemorrhage of the tumors (P<0.05), but has nothing to do with the expression of P73 (P>0.05).There is no statistical difference between calcification and the expression of Ki67, MVD, P73 (P>0.05). Conclusion 1, An accurate preoperative diagnosis of CCRCC can be made by MSCT scanning. 2, Some of CT features of CCRCC have correlation with the expression of Ki67, MVD and P73, it illustrate that CT manifestation of CCRCC may reflect the biological characteristic of the tumors partly.
【关键词】计算机体层摄影;肾细胞癌; Ki67抗原;微血管密度;P73抗原
【中图分类号】R445.3;R737.11
【文献标识码】A
【DOI】 10.3969/j.issn.1672-5131.2015.01.17
前言
肾细胞癌起源于肾脏近曲小管上皮细胞,是肾脏最常见的原发肿 瘤[1],目前肾癌的检查方法较多,但CT仍然是应用最广泛的肾癌检查 方法[6]。本研究将肾透明细胞癌的CT表现与肿瘤组织的MVD、Ki67、 P73的表达进行对比研究,探讨它们之间的相关性,以求更进一步提高 术前诊断符合率,并为其术前方案的制定及预后评价提供参考。
中国CT和MRI杂志
第13卷, 第 1 期
2015年01月
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