Different Expression of IFITM5 in Cancer Cell Lines*
Author：HAN Feng1,2, LU Yan-qin2, WANG Yan-zhou3, et al.
affiliation：1 School of Medicine and Life Sciences, University of Jinan-Shandong; Academy of Medical Sciences, Jinan 250022,China; 2 Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China,et al.
PDFAbstract
Objective To investigate the expression level of IFN-inducible transmembrane protein 5(IFITM5) in 15 different cancer cell lines. Methods RT-QPCR and Western blot were performed to detect the expression level of IFITM5 in SAOS2,3A0, SKOV3, HEPG2, HEP2, ACCM, HT29, MDA-MB-231, H7402, HELA, HEK-293, HL-60, K562, THP1 and RD cancer cell lines. Results There was remarkable difference in the expression of IFITM5 in this cancer cell lines.The lowest expression level of mRNA and protein were detected in H7402,RD and HEP2 cell lines .The highest IFITM5 expression was observed in SAOS2 cells,followed by 3AO. Conclusions Significant differential expression of IFITM5 in 15 cancer cells was observed, which laid the foundation for further research on the relationship of IFITM5 and tumor.
【Keyword】IFITM5; MRNA; Protein; Cancer Cell Lines
【Chart number】R73-3
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2015.02.014
Journal of Rare Diseases
th22Volume， th 2 Issue
2019Year11Month
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