Objective To observe Shengmai Injection in improving qi deficiency syndrome in advanced breast Cancer patients. Methods Seventy advanced breast cancer patients were divided into two groups randomized, 35 patients were control group and 38 patients were experimental group. All patients were received intravenous nutrition. The latter had been received Shengmai injection (50 m1) eontaining 5% GS 500 ml once a day for two weeks. The qi deficiency syndrome and peripheral white blood cells, lymphocyte ,red cell were evaluated after two weeks. Results The qi deficiency syndrome were relieved in both group, and effective rate of the experimental group is higher than the control group (P ＜0.05). The total lymphocyte count were increased in the experimental group. Conclusion Sheng mai inject ion can effectively relive the qi deficiency syndrome and improve the immunity function of advanced breast cancer patients.