Objective To investigate the value of CT angiography in percutaneous coronary intervention for chronic total occlusion (CTO). Methods The data of 210 CTO patients admitted to our hospital from June 2014 to December 2016 were analyzed, and patients were divided into two groups according to the different preoperative evaluation methods, and 106 patients in the control group received routine assessment before operation, while 104 patients in the observation group received the CT angiography before operation. Then the operative success rate, left ventricular systolic function, and complications were compared between the two groups, moreover, the characteristics of CTO regression were analyzed. Results The success rate of patients in the observation group was significantly higher than that in the control group(P<0.05). The preoperative left ventricular wall motion index and left ventricular ejection fraction between the two groups had no difference(P>0.05), which were ameliorated after operation, and the observation group had lower left ventricular wall motion index as well as higher left ventricular ejection fraction than those of the control group(P<0.05). The total incidence of complications in the observation group was significantly lower than that in the control group(P<0.05). Multivariate logistic regression analysis showed that the unambiguous distal fibrous cap of the occlusion segment and the occlusion of the proximal branch as well as the occlusion length ≥20 mm were the main factors affecting the failure of CTO intervention. Conclusion CT angiography plays an important role in evaluating the effect of percutaneous coronary intervention on chronic total occlusion, which can significantly increase the success rate of percutaneous coronary intervention, and improve the ventricular function, and reduce complications. It is worthy of recommendation.