Objective To investigate the diagnostic value of multi-slice computed tomography dynamic contrast enhanced scan in renal chromophobe cell carcinoma. Methods Retrospective analysis of 12 cases of pathologically confirmed chromophobe renal cell carcinoma patients with CT imaging data. All preoperative CT scan and threeperiod dynamics enhanced scan. Results Number of lesions: 12 lesions were single. Lesion morphology, size: of which 10 cases were round or oval-shaped lesions, 2 cases were mildly lobulated. The average maximum diameter is 6.8cm. Lesion density: CT scan most of the same density or low density, density uniformity in 7 cases, of which 2 cases of pseudocapsule. Density uneven in 5 cases, no obvious fake mask, of which 1 case of lesions seen scattered in the point-like, strip calcification, 3 cases of cystic necrosis within the cystic area, 1 case of stenosis see the star-shaped scar. CT scan lesions were equal density or slightly lower density. Enhanced scan 1 case was "fast forward fast" type enhanced, 10 cases were "light-moderate" persistent enhancement, 1 case was "slow into the slow out" type enhanced. All levels of tumor enhancement were lower than those of renal cortex. All the lesions were not seen perirenal invasion, renal vein and inferior vena cava tumor thrombus formation and retroperitoneal lymph node metastasis. Conclusion The lightmoderate persistence enhancement shown by the dynamic CT enhanced scan of the chromosomal cell carcinoma of the kidney has certain characteristics. Preoperative CT examination can provide some reference value for the qualitative diagnosis and differential diagnosis of the tumor.