Objective To explore the value of multislice spiral CT (MSCT) in assessing the left ventricular function in patients with coronary heart disease (CHD). Methods A total of 98 patients with CHD (study group) and 30 healthy volunteers (healthy group) who admitted to our hospital during January 2016 -February 2017 were selected as subjects. All subjects underwent MSCT scanning, and imaging features were observed. The left ventricular function [left ventricular end-diastolic dimension(LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection time (LVET), left ventricular ejection fraction (LVEF)] were compared among groups. The correlation between the degree of stenosis and the left ventricular function in patients with CHD was analyzed. Results Compared with the healthy group, EDV and ESV in mild group, moderate group and severe group were significantly higher, while SV and EF were lower, with statistically significant difference between any two groups (P<0.05). Compared with non-calcification group, EDV and ESV in mild calcification group, moderate calcification group and severe calcification group were significantly higher, while SV and EF were lower, with statistically significant difference between any two groups (P<0.05). MSCT scan could well show the short axis and long axis images of the left ventricle in patients with CHD. It could clearly show the diastolic volume and systolic volume of patients with CHD, and accurately measure the degree of vascular stenosis and calculate the calcification score. Conclusion MSCT not only can accurately assess the degree of coronary artery stenosis and calcification in patients with CHD, but also can be used to analyze left ventricular function parameters. One-time scanning is with effects of morphological display and functional analysis, providing valuable information for clinical diagnosis of CHD.