Objective The correlation between CT findings and clinical pathological characteristics and vascular endothelial growth factor in hepatocellular carcinoma patients. Methods 98 cases of patients with hepatocellular carcinoma from October 2014 to January 2016 in our hospital were selected, preoperative CT scans of patients with tumor size, liver cirrhosis, venous invasion, lymph node enlargement was analyzed, The results were compared with the pathological results after operation, and the vascular endothelial growth factor (VEGF) was detected and compared with the CT findings, and the correlation between the VEGF and CT findings was analyzed. Results Tumor diameter greater than 5 cm and the number of patients with carcinoma of PVTT comparison does not have statistical differences (P>0.05), cirrhosis of the liver and lymph nodes in patients with test results there was significant difference between them (P<0.05), the expression of CT and VEGF are related to the tumor edge definition, tumor necrosis, and there is no PVTT (P<0.05), CT manifestations of tumor diameter, tumor free arteries and the expression of VEGF (P>0.05). Conclusion CT can be a more accurate response to the basic situation of patients with hepatocellular carcinoma, but there are still some deficiencies, VEGF expression and CT have a greater relationship.