Objective To preliminarily discuss the value of skin CT in the staging of vitiligo. Methods A total of thirty patients with vitiligo admitted to the department of dermatology of the hospital from April 2017 to April 2018 were selected as study subjects. The degree of activity of vitiligo (VIDA) score and skin CT features were used for staging of vitiligo. Five patients with progressive vitiligo and 5 patients with stable vitiligo were selected. The immunohistochemical staining was performed at sites examined by skin CT. Results The staging of VIDA score showed 7 cases in rapid progressive stage, 10 cases in slow progressive stage and 13 cases in stable stage. The staging according to skin CT features showed 6 cases in rapid progressive stage, 9 cases in slow progressive stage and 15 cases in stable stage. There was no significant difference in staging of vitiligo between the two methods (P>0.05). The characteristics of skin CT images were as follows. Progressive vitiligo manifested as loss of integrity of the basal pigment ring in the vitiligo area, obviously decreased content of pigments on residual pigment ring, blurred boundaries with normal skin and some patients with high refractive cells in the superficial dermis. Stable vitiligo manifested as complete loss of basal pigment ring, clear boundaries with the surrounding skin, intact normal pigment rings at edges of skin lesions and some patients with dendritic melanin around the hair follicles of skin lesions. Immunohistochemistry showed that there was significant lymphocytic infiltration of progressive vitiligo lesions but no lymphocytic infiltration of stable vitiligo lesions. Conclusion Skin CT can be used as an important method to judge the stage of vitiligo. The presence or absence of lymphocyte infiltration at lesions of vitiligo can be used as an important basis for distinguishing progressive and stable vitiligo.