Objective To analyze thebrain CT features of infantile Sturge-Weber syndrome. Methods Sixty-three infantswith Sturge-Weber syndrome diagnosed in the hospital from January 2012 to December 2017 and with complete CT imaging data were enrolled in the retrospective analysis. The involved sites, density of affected lobes, signal density of lobs, boundary of brain gray matter, choroid plexus, shape of brain atrophy, the presence of subdural hemorrhage or effusion were analyzed through brain CT imaging data of infantile Sturge-Weber syndrome. Results There were typical calcifications in brains of 63 children, mainly distributed along the gyrus and sulcus. 34 cases were curveshaped, 19 cases were ribbon shaped and 10 cases were curved tube shaped. Among them, there were 10 cases in the temporoparietal lobe, 33 cases in occipital parietal lobe and 11 cases in frontoparietal region. 27 cases of calcified foci were on the same side of the facial hemangioma, mainly involving the cortex. There was different degrees of widening in local sulcus, cisternand subarachnoid space. There was different degrees of brain atrophy on the same side of soft meningeal hemangiomas, manifesting as enlargement of the ventricles, widening of the sulci and cerebral hemisphere on the same side of lesions larger than calcified areas. 55 cases were focal brain atrophy, and the rest cases were extensive brain atrophy. Enhanced CT scanning showed line-like and gyrus-like enhancement on the surface of the cortex, and the extent of gyrus-likeenhancement was significantly larger than that of the calcified range. CTA showed abnormal venous shadow. CT enhanced scan of 31 cases showed obvious thickening of the lateral cerebral choroid plexus, and the scope expanded, with obvious enhancement. CT bone window showed obvious thickening of the skull adjacent to ipsilateral calcified brain tissues in 41 cases and subdural effusion on the same side of vascular malformations in 32 cases, without bleeding. Conclusion The typical CT features of infantile Sturge-Weber syndrome include intracranial local calcification, cerebral pia mater hemangioma and local brain atrophy, suggesting that CT combined with clinical manifestations and MRI can further confirm the diagnosis of Sturge-Weber syndrome.