Objective To analyze the clinical features and imaging findings of CT and MRI of patients with brain gray matter heterotopia. Methods The clinical data of 56 patients with brain gray matter heterotopia treated in the hospital from June 2013 to July 2016 were collected. All patients received plain scan and enhanced scan of CT and MRI. The clinical features and imaging findings were summarized. Results Most of the enrolled patients with brain gray matter heterotopia were male adolescents under the age of 18. Most of the patients were treated because of epilepsy, and lesions were solitary. Brain gray matter nodules located in under the tympanic membrane accounted for 41.07%, nonsubependymal nodules accounted for 55.36%, and mixed type accounted for 3.57%. CT scan found that the brain gray matter of patients with brain gray matter heterotopia showed relatively high density which was the same with cortical density. Enhanced scan showed no enhancement, no edema or obvious mass effect unless huge brain gray matter heterotopia. MRI T1WI and T2WI sequences of heterotopic brain gray matter showed equal cortical signals which were consistent with normal cortical signals. There was nodular, massive, banded or platy signal shadow, and there was no edema around and no space occupying effect. Enhanced scan showed no enhancement. Conclusion Brain gray matter heterotopia is common in male adolescents, the common type is subependymal type, and most lesions are nodular. Both of CT and MRI can better display ectopic foci of gray matter, but the resolution of soft tissue displayed by MRI is relatively higher.