Objective To explore the clinical features and CT imaging of bronchiolitis obliterans in children. Methods The clinical data of 60 children with bronchiolitis obliterans in the department of pediatrics of our hospital were retrospectively analyzed. All the children were given the pulmonary CT examination, and the clinical manifestations and CT imaging features were analyzed. Results In terms of clinical symptoms, there were 32 cases (53.3%) of patients with persistent cough, shortness of breath and dyspnea, and 39 cases (65.0%) with intermittent fever and 28 cases (46.7%) with shortness of breath after activities. From the respect of physical examination in the lungs, there were 37 cases (80.4%) of dry and wet rales, and 44 cases (73.3%) with wheezing rales and 28 cases (46.7%) with combined three depressions sign. Pulmonary CT examination showed that there were 43 cases (71.7%) of patients with mosaic perfusion, 3 cases (5.0%) with unilateral transparent lung, 20 cases (33.3%) with bronchial wall thickening, 6 cases (10.0 %) with combined pulmonary atelectasis, 13 cases (21.7%) with combined bronchial dilatation and 4 cases (6.7%) with bronchial mucus. Conclusion Pulmonary CT can clearly show the small airway morphological changes, and has the noninvasive, accurate and repeatable advantages compared with the pathogen examination and pulmonary function test, and it can provide a certain reference value for the clinical diagnosis.