Objective To comprehensively analyze the multi-slice spiral CT diagnosis of myocardial bridge and coronary artery and its clinical significance and its effect on cardiac function. Methods 91 patients with myocardial bridge and wall coronary artery were treated with multi-slice spiral CT in our hospital. SPSS20.0 statistical software was used to analyze the number of segments and the proportion of cardiomyocytes and coronal arteries in different segments of the coronary artery. The depth of the myocardial bridge, the length of the coronary artery, the morphology of the myocardial bridge and the coronary artery (Left ventricular end-systolic volume, end-diastolic volume, stroke volume, cardiac output, left ventricular ejection fraction), and atherosclerotic plaque left in patients with different degrees of coronary artery disease Heart function related indicators. Results ①91 cases of myocardial bridge and coronary artery were detected in 126 patients, myocardial bridge and coronary artery in different segments of the coronary artery in the highest proportion of the middle of the anterior descending artery, followed by the anterior descending artery (P <0.05). ② The average depth of the myocardial bridge was (1.88± 0.26) mm, and the average length of the coronary artery was (21.69±2), and the mean length of the coronary artery was (21.69±9.33) mm. ③ Morphological manifestations of cardiac and wall coronary arteries: Coronary trunk and branches are in the myocardium, local changes, panicle changes, milking phenomenon. ④ different degree of stenosis of the coronary artery (P<0.05). There was no significant difference in the volume of left ventricular systolic volume (P>0.05), and there was no significant difference in left ventricular end-systolic volume (P>0.05) There was no significant difference in left ventricular end-systolic volume, end-diastolic volume, stroke volume, cardiac output and left ventricular ejection fraction (P>0.05). Conclusion The value of multi - slice spiral CT in diagnosis of myocardial bridge and coronary artery is relatively high, which can clearly show the basic characteristics of morphology. Coronary artery stenosis can lead to the decline of left ventricular function.