Objective To explore the value of dual-source CT low dose scanning technique in the diagnosis of mesenteric ischemic disease. Methods The results of different doses of dual source CT in the diagnosis of mesenteric ischemic disease were retrospectively analyzed. Results There were no significant differences in personality parameters (sex ratio, age, BMI) and scanning length between the two groups (P>0.05). The subjective score of the image quality of the two groups was high, and there was no significant difference between the two groups (P>0.05). The average effective radiation dose was (2.43±0.76) mSv in the control group and (4.21±1.33)mSv in the observation group, The average radiation dose received by the patients in the observation group was significantly lower than that of the control group, the difference was Statistical significance(P<0.05). The accuracy of the two groups was 100% in the diagnosis of mesenteric vascular lesions by angiography and surgical outcome. Conclusion The dual source CT low dose scanning scheme has a high accuracy in the diagnosis of mesenteric ischemic disease and reduces the dose of radiation. It is of great value for popularization.